NUTRIM, School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+, Maastricht, the Netherlands.
NUTRIM, School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+, Maastricht, the Netherlands; Institute of Sports and Exercise Studies, HAN University of Applied Sciences, Nijmegen, the Netherlands.
Free Radic Biol Med. 2020 May 20;152:295-300. doi: 10.1016/j.freeradbiomed.2020.03.025. Epub 2020 Mar 26.
Extensive research performed over the past 10 years has resulted in dietary nitrate being considered a nutritional supplement that can improve exercise performance. However, there is still limited insight in the metabolic fate of dietary nitrate following the appearance of nitrate and nitrite in the circulation. Recent observations in humans suggest the storage of nitrate in skeletal muscle tissue. This short review discusses the possibility of nitrate being stored and utilized in human skeletal muscle tissue, and why confirming this may increase our understanding of how the nitrate-nitrite-NO pathway improves exercise performance. Further insight in skeletal muscle nitrate storage and metabolism may provide answers to current gaps in knowledge, such as the ergogenic benefit of acute vs multiday dietary nitrate supplementation, as well as the suggested muscle fiber-type specific effects on exercise performance. In this mini-review, specific questions that need further exploration are also discussed.
在过去的 10 年中进行了广泛的研究，结果表明膳食硝酸盐可被视为一种营养补充剂，可提高运动表现。然而，在硝酸盐和亚硝酸盐出现在循环中之后，对于膳食硝酸盐的代谢命运仍然知之甚少。最近在人类中的观察结果表明，硝酸盐储存在骨骼肌组织中。这篇简短的综述讨论了硝酸盐在人类骨骼肌组织中被储存和利用的可能性，以及为什么确认这一点可能会增加我们对硝酸盐-亚硝酸盐-NO 途径如何改善运动表现的理解。进一步了解骨骼肌中硝酸盐的储存和代谢可能会为当前知识空白提供答案，例如急性与多日膳食硝酸盐补充的功效益处，以及对运动表现的建议的肌纤维类型特异性影响。在这个小型综述中，还讨论了需要进一步探索的具体问题。
