Muckle D S
Rheumatol Rehabil. 1977 Feb;16(1):58-61. doi: 10.1093/rheumatology/16.1.58.
A double-blind trial of flurbiprofen (150 mg daily) and aspirin (3.6 g daily) for six days was carried out in 52 soft-tissue injuries in 28 professional footballers. An analysis of daily pain scores in both injury categories (trauma and sprains) showed that players taking flurbiprofen had significantly lower pain scores from day 2 onwards compared to the aspirin group (P less than 0.01), the effect being more marked in the trauma subgroup. Flurbiprofen was significantly better than aspirin in reducing the time taken to achieve both training and match fitness, and 65% of the players taking flurbiprofen were able to train within three days of injury compared to 35% taking aspirin (P less than 0.05). The possible effects of both anti-inflammatory agents on prostaglandin metabolism are discussed, and their role in soft-tissue trauma outlined.
对28名职业足球运动员的52处软组织损伤进行了一项双盲试验，比较氟比洛芬（每日150毫克）和阿司匹林（每日3.6克），为期6天。对两类损伤（创伤和扭伤）的每日疼痛评分分析表明，与阿司匹林组相比，服用氟比洛芬的球员从第2天起疼痛评分显著更低（P小于0.01），在创伤亚组中这种效果更明显。在缩短恢复训练和比赛体能所需时间方面，氟比洛芬显著优于阿司匹林，服用氟比洛芬的球员中有65%在受伤后三天内能够恢复训练，而服用阿司匹林的这一比例为35%（P小于0.05）。文中讨论了两种抗炎药对前列腺素代谢的可能影响，并概述了它们在软组织创伤中的作用。
