• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

含非甾体抗炎药（NSAIDs）酮洛芬和萘普生的 Pt(IV) 缀合物的抗增殖活性。

Antiproliferative Activity of Pt(IV) Conjugates Containing the Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) Ketoprofen and Naproxen .

机构信息

Dipartimento di Scienze e Innovazione Tecnologica, Università del Piemonte Orientale, Viale T. Michel 11, 15121 Alessandria, Italy.

出版信息

Int J Mol Sci. 2019 Jun 24;20(12):3074. doi: 10.3390/ijms20123074.

DOI:10.3390/ijms20123074
PMID:31238499
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6627341/
Abstract

Cisplatin and several non-steroidal anti-inflammatory drugs (NSAIDs) have been proven to act synergistically or at least additively on several tumor cell lines. Dual-action cisplatin-based Pt(IV) combos containing ketoprofen and naproxen offer good antiproliferative performance on a panel of human tumor cell lines, including a malignant pleural mesothelioma (MPM) one, a very chemoresistant tumor. The main reason of the increased activity relies on the enhanced lipophilicity of these Pt(IV) conjugates that in turn promotes increased cellular accumulation. A quick Pt(IV)→Pt(II) reduction generates the active cisplatin metabolite. The NSAID adjuvant action seems to be almost independent from cyclooxygenase-2 () expression in the tumor cells under investigation (lung A-549, colon HT-29, HCT 116, SW480, ovarian A2780, and biphasic MPM MSTO-211H), but it seems to rely (at least in part) on the activation of the NSAID activated gene, (a member of the transforming growth factor beta, , superfamily), which has been suggested to be involved in NSAID antiproliferative activity.

摘要

顺铂和几种非甾体抗炎药 (NSAIDs) 已被证明在几种肿瘤细胞系上协同作用或至少相加作用。含有酮洛芬和萘普生的双功能基于顺铂的 Pt(IV) 组合对一系列人类肿瘤细胞系，包括恶性胸膜间皮瘤 (MPM)，一种非常耐药的肿瘤，具有良好的抗增殖作用。活性增强的主要原因在于这些 Pt(IV) 缀合物的亲脂性增强，进而促进细胞内积累增加。快速的 Pt(IV)→Pt(II) 还原生成活性顺铂代谢物。在研究中的肿瘤细胞（肺 A-549、结肠 HT-29、HCT 116、SW480、卵巢 A2780 和双相 MPM MSTO-211H）中，NSAID 辅助作用似乎几乎独立于环氧化酶-2 () 的表达，但它似乎依赖于（至少部分）对 NSAID 激活基因的激活， （转化生长因子β、、超家族的一个成员），这被认为与 NSAID 的抗增殖活性有关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ece/6627341/d2ec022d01bc/ijms-20-03074-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ece/6627341/b32f24a2c8ea/ijms-20-03074-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ece/6627341/eb855404547b/ijms-20-03074-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ece/6627341/991781c63bf4/ijms-20-03074-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ece/6627341/f2717ec726f4/ijms-20-03074-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ece/6627341/9aa893af940f/ijms-20-03074-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ece/6627341/ae8d2927d04c/ijms-20-03074-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ece/6627341/331443924cf4/ijms-20-03074-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ece/6627341/d2ec022d01bc/ijms-20-03074-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ece/6627341/b32f24a2c8ea/ijms-20-03074-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ece/6627341/eb855404547b/ijms-20-03074-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ece/6627341/991781c63bf4/ijms-20-03074-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ece/6627341/f2717ec726f4/ijms-20-03074-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ece/6627341/9aa893af940f/ijms-20-03074-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ece/6627341/ae8d2927d04c/ijms-20-03074-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ece/6627341/331443924cf4/ijms-20-03074-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ece/6627341/d2ec022d01bc/ijms-20-03074-g008.jpg

相似文献

1
Antiproliferative Activity of Pt(IV) Conjugates Containing the Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) Ketoprofen and Naproxen .含非甾体抗炎药（NSAIDs）酮洛芬和萘普生的 Pt(IV) 缀合物的抗增殖活性。
Int J Mol Sci. 2019 Jun 24;20(12):3074. doi: 10.3390/ijms20123074.
2
Pt(IV) Prodrugs with NSAIDs as Axial Ligands.以非甾体抗炎药作为轴向配体的铂（IV）前药。
Int J Mol Sci. 2021 Apr 7;22(8):3817. doi: 10.3390/ijms22083817.
3
The cisplatin-based Pt(iv)-diclorofibrato multi-action anticancer prodrug exhibits excellent performances also under hypoxic conditions.基于顺铂的 Pt(iv)-二氯菲罗嗪多作用抗癌前药在缺氧条件下也表现出优异的性能。
Dalton Trans. 2018 Jun 25;47(25):8268-8282. doi: 10.1039/c7dt04614f.
4
Novel Antitumor Platinum(II) Conjugates Containing the Nonsteroidal Anti-inflammatory Agent Diclofenac: Synthesis and Dual Mechanisms of Antiproliferative Effects.含非甾体抗炎药双氯芬酸的新型抗肿瘤铂（II）缀合物：合成及抗增殖作用的双重机制
Inorg Chem. 2017 Feb 6;56(3):1483-1497. doi: 10.1021/acs.inorgchem.6b02553. Epub 2017 Jan 19.
5
Functional fluorescent nonporous silica nanoparticles as carriers for Pt(IV) anticancer prodrugs.功能性荧光无孔二氧化硅纳米颗粒作为铂（IV）抗癌前药的载体
J Inorg Biochem. 2015 Oct;151:132-42. doi: 10.1016/j.jinorgbio.2015.08.001. Epub 2015 Aug 6.
6
New NSAID-Pt(IV) prodrugs to suppress metastasis and invasion of tumor cells and enhance anti-tumor effect in vitro and in vivo.新型 NSAID-Pt(IV)前药可抑制肿瘤细胞的转移和侵袭，并增强体内外的抗肿瘤效果。
Eur J Med Chem. 2019 Apr 1;167:377-387. doi: 10.1016/j.ejmech.2019.02.041. Epub 2019 Feb 13.
7
Functionalized nonporous silica nanoparticles as carriers for Pt(iv) anticancer prodrugs.功能化无孔二氧化硅纳米颗粒作为铂（IV）抗癌前药的载体
Dalton Trans. 2016 Nov 1;45(43):17233-17240. doi: 10.1039/c6dt03133a.
8
Cis,cis,trans-[PtCl(NH)(perillato)], a dual-action prodrug with excellent cytotoxic and antimetastatic activity.顺式,顺式,反式-[PtCl(NH)(川芎嗪)], 一种具有优异细胞毒性和抗转移活性的双重作用前药。
Dalton Trans. 2021 Mar 7;50(9):3161-3177. doi: 10.1039/d0dt04051g. Epub 2021 Feb 17.
9
Photoactive platinum(II) complexes of nonsteroidal anti-inflammatory drug naproxen: Interaction with biological targets, antioxidant activity and cytotoxicity.非甾体抗炎药萘普生的光活性铂（II）配合物：与生物靶点的相互作用、抗氧化活性和细胞毒性。
Eur J Med Chem. 2018 Jan 20;144:243-254. doi: 10.1016/j.ejmech.2017.12.025. Epub 2017 Dec 8.
10
Alternative mechanism of action of the DNP Pt prodrug: intracellular cisplatin release and the mitochondria-mediated apoptotic pathway.DNP Pt 前药的另一种作用机制：细胞内顺铂释放和线粒体介导的细胞凋亡途径。
Dalton Trans. 2021 Jun 15;50(23):7922-7927. doi: 10.1039/d1dt00898f.

引用本文的文献

1
Hybrid Platinum(IV)-Naproxen Nanostructured Drugs Reprogram Melanoma Cells and Overpower Cisplatin.铂（IV）-萘普生混合纳米结构药物可重编程黑色素瘤细胞并战胜顺铂。
Nanomaterials (Basel). 2025 Aug 28;15(17):1320. doi: 10.3390/nano15171320.
2
Design, Synthesis, and Evaluation of New 2-Arylpropanoic Acid-l-Tryptophan Derivatives for Mitigating Cisplatin-Induced Nephrotoxicity.新型2-芳基丙酸-L-色氨酸衍生物减轻顺铂诱导的肾毒性的设计、合成与评价
Molecules. 2025 May 30;30(11):2400. doi: 10.3390/molecules30112400.
3
Interpreting the function of cell penetrating peptide (RGD) in drug transport to the cell membrane: a computational approach.

本文引用的文献

1
Applications of heteronuclear NMR spectroscopy in biological and medicinal inorganic chemistry.异核核磁共振光谱在生物与药物无机化学中的应用。
Coord Chem Rev. 2008 Nov;252(21):2239-2277. doi: 10.1016/j.ccr.2008.01.016. Epub 2008 Jan 26.
2
Regulation of apoptosis in health and disease: the balancing act of BCL-2 family proteins.凋亡在健康和疾病中的调控：BCL-2 家族蛋白的平衡作用。
Nat Rev Mol Cell Biol. 2019 Mar;20(3):175-193. doi: 10.1038/s41580-018-0089-8.
3
Toward Multi-Targeted Platinum and Ruthenium Drugs-A New Paradigm in Cancer Drug Treatment Regimens?
解析细胞穿透肽（RGD）在药物向细胞膜转运中的功能：一种计算方法。
Sci Rep. 2024 Nov 29;14(1):29668. doi: 10.1038/s41598-024-80060-7.
4
Gold(I) Complexes Based on Nonsteroidal Anti-Inflammatory Derivatives as Multi-Target Drugs against Colon Cancer.基于非甾体类抗炎衍生物的金（I）配合物作为治疗结肠癌的多靶药物。
Inorg Chem. 2024 Oct 21;63(42):19769-19782. doi: 10.1021/acs.inorgchem.4c02988. Epub 2024 Oct 10.
5
Causal relationship between anti-inflammatory drugs and cancer: a pan-cancer study with Mendelian randomization.抗炎药物与癌症之间的因果关系：一项孟德尔随机化的全癌研究
Front Genet. 2024 May 24;15:1392745. doi: 10.3389/fgene.2024.1392745. eCollection 2024.
6
Tumor-targeted dual-action NSAID-platinum(iv) anticancer prodrugs.肿瘤靶向双作用非甾体抗炎药-铂（IV）抗癌前药
Inorg Chem Front. 2023 Jun 28;10(14):4126-4138. doi: 10.1039/d3qi00968h. eCollection 2023 Jul 11.
7
Synthesis, Characterization and Biological Investigation of the Platinum(IV) Tolfenamato Prodrug-Resolving Cisplatin-Resistance in Ovarian Carcinoma Cell Lines.铂（IV）替拉那ATO 前药的合成、表征及解决顺铂耐药性在卵巢癌细胞系中的生物学研究。
Int J Mol Sci. 2023 Mar 16;24(6):5718. doi: 10.3390/ijms24065718.
8
Perspectives of the Application of Non-Steroidal Anti-Inflammatory Drugs in Cancer Therapy: Attempts to Overcome Their Unfavorable Side Effects.非甾体抗炎药在癌症治疗中的应用前景：克服其不良副作用的尝试
Cancers (Basel). 2023 Jan 12;15(2):475. doi: 10.3390/cancers15020475.
9
Microwave-Assisted Synthesis: Can Transition Metal Complexes Take Advantage of This "Green" Method?微波辅助合成：过渡金属配合物能利用这种“绿色”方法吗？
Molecules. 2022 Jun 30;27(13):4249. doi: 10.3390/molecules27134249.
10
Interactions of Analgesics with Cisplatin: Modulation of Anticancer Efficacy and Potential Organ Toxicity.镇痛药与顺铂的相互作用：抗癌疗效的调节及潜在的器官毒性
Medicina (Kaunas). 2021 Dec 28;58(1):46. doi: 10.3390/medicina58010046.
迈向多靶点铂类和钌类药物——癌症药物治疗方案的新模式？
Chem Rev. 2019 Jan 23;119(2):1058-1137. doi: 10.1021/acs.chemrev.8b00271. Epub 2019 Jan 14.
4
Synthesis and characterization of cyclohexane-1R,2R-diamine-based Pt(iv) dicarboxylato anticancer prodrugs: their selective activity against human colon cancer cell lines.基于环己烷-1R,2R-二胺的 Pt(iv) 二羧酸抗癌前药的合成与表征：它们对人结肠癌细胞系的选择性活性。
Dalton Trans. 2019 Jan 2;48(2):435-445. doi: 10.1039/c8dt03950j.
5
Multi-action Pt(IV) anticancer agents; do we understand how they work?多靶点铂(IV)抗癌剂；我们是否了解其作用机制？
J Inorg Biochem. 2019 Feb;191:77-84. doi: 10.1016/j.jinorgbio.2018.11.008. Epub 2018 Nov 15.
6
Pt(iv) derivatives of cisplatin and oxaliplatin with phenylbutyrate axial ligands are potent cytotoxic agents that act by several mechanisms of action.顺铂和奥沙利铂与苯丁酸盐轴向配体形成的铂（IV）衍生物是通过多种作用机制发挥作用的强效细胞毒剂。
Chem Sci. 2016 Mar 1;7(3):2381-2391. doi: 10.1039/c5sc04205d. Epub 2016 Jan 15.
7
The cisplatin-based Pt(iv)-diclorofibrato multi-action anticancer prodrug exhibits excellent performances also under hypoxic conditions.基于顺铂的 Pt(iv)-二氯菲罗嗪多作用抗癌前药在缺氧条件下也表现出优异的性能。
Dalton Trans. 2018 Jun 25;47(25):8268-8282. doi: 10.1039/c7dt04614f.
8
The side effects of platinum-based chemotherapy drugs: a review for chemists.铂类化疗药物的副作用：化学家的综述。
Dalton Trans. 2018 May 15;47(19):6645-6653. doi: 10.1039/c8dt00838h.
9
A Carrier-Free Nanostructure Based on Platinum(IV) Prodrug Enhances Cellular Uptake and Cytotoxicity.基于顺铂前药的无载体纳米结构增强细胞摄取和细胞毒性。
Mol Pharm. 2018 Apr 2;15(4):1724-1728. doi: 10.1021/acs.molpharmaceut.8b00070. Epub 2018 Mar 14.
10
Biotin conjugated organic molecules and proteins for cancer therapy: A review.用于癌症治疗的生物素缀合有机分子和蛋白质：综述。
Eur J Med Chem. 2018 Feb 10;145:206-223. doi: 10.1016/j.ejmech.2018.01.001. Epub 2018 Jan 2.