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射血分数保留的心力衰竭与肥胖：绝经后女性的cGMP-PKG缺乏综合征

Heart Failure with Preserved Ejection Fraction and Obesity: Syndrome of cGMP-PKG Deficiency in Post-Menopausal Women.

作者信息

Sinha Arjun, Yancy Clyde W, Shah Sanjiv J, Khan Sadiya S

机构信息

Department of Preventive Medicine, Northwestern University Feinberg School of Medicine.

Division of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine.

出版信息

JACC Case Rep. 2020 Jan;2(1):28-32. doi: 10.1016/j.jaccas.2019.11.065. Epub 2020 Jan 15.

DOI:10.1016/j.jaccas.2019.11.065
PMID:32226944
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7100876/
Abstract

The authors report a case of heart failure with preserved ejection fraction in a post-menopausal woman with obesity. The case highlights a metabolic phenotype of heart failure with preserved ejection fraction that commonly presents in women with discussion focusing on the pathophysiology, mechanistic pathways, and potential targeted therapeutic strategies.

摘要

作者报告了一例肥胖绝经后女性射血分数保留的心力衰竭病例。该病例突出了射血分数保留的心力衰竭的一种代谢表型，这种表型常见于女性，讨论集中在病理生理学、机制途径和潜在的靶向治疗策略上。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/331c/8301710/d19a77054788/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/331c/8301710/f1849a89e0a5/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/331c/8301710/b7597ffad7cb/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/331c/8301710/45020f053ed3/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/331c/8301710/d19a77054788/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/331c/8301710/f1849a89e0a5/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/331c/8301710/b7597ffad7cb/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/331c/8301710/45020f053ed3/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/331c/8301710/d19a77054788/gr3.jpg

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N Engl J Med. 2019 Oct 24;381(17):1609-1620. doi: 10.1056/NEJMoa1908655. Epub 2019 Sep 1.
2
A Simple, Evidence-Based Approach to Help Guide Diagnosis of Heart Failure With Preserved Ejection Fraction.一种简单、基于证据的方法，有助于指导射血分数保留的心力衰竭的诊断。
Circulation. 2018 Aug 28;138(9):861-870. doi: 10.1161/CIRCULATIONAHA.118.034646.
3
Evidence Supporting the Existence of a Distinct Obese Phenotype of Heart Failure With Preserved Ejection Fraction.
JACC Basic Transl Sci. 2020 Mar 23;5(3):296-299. doi: 10.1016/j.jacbts.2020.02.001. eCollection 2020 Mar.
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Circ Heart Fail. 2016 Oct;9(10). doi: 10.1161/CIRCHEARTFAILURE.115.002883.
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