Ding Ting-Hui, Qu Jian-Ping, Kang Yan-Biao
Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, China.
Institute of Advanced Synthesis, School of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing 211816, China.
Org Lett. 2020 Apr 17;22(8):3084-3088. doi: 10.1021/acs.orglett.0c00827. Epub 2020 Mar 31.
We report a simple and efficient visible-light-induced transition-metal-free hydrogenation of aryl halides. The combined visible light and base system is used to initiate the desired radical-mediated hydrogenation. A variety of aryl fluorides, chlorides, bromides, and iodides could be reduced to the corresponding (hetero)arenes with excellent yields under mild conditions. Various functional groups and other heterocyclic compounds are tolerated.
我们报道了一种简单高效的可见光诱导的无过渡金属芳基卤化物氢化反应。可见光和碱的组合体系用于引发所需的自由基介导的氢化反应。在温和条件下，各种芳基氟化物、氯化物、溴化物和碘化物都可以被还原为相应的（杂）芳烃，产率优异。该反应对各种官能团和其他杂环化合物均具有耐受性。
