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从 2018 年 6 月到 2021 年 10 月的历程，反应物为二甲基甲酰胺和二甲基乙酰胺。

A Journey from June 2018 to October 2021 with ,-Dimethylformamide and ,-Dimethylacetamide as Reactants.

机构信息

Institut de Chimie Moléculaire de Reims, CNRS-Université de Reims Champagne-Ardenne, B.P. 1039, CEDEX 2, 51687 Reims, France.

出版信息

Molecules. 2021 Oct 21;26(21):6374. doi: 10.3390/molecules26216374.

DOI:10.3390/molecules26216374
PMID:34770783
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8587108/
Abstract

A rich array of reactions occur using ,-dimethylformamide (DMF) or ,-dimethylacetamide (DMAc) as reactants, these two amides being able to deliver their own H, C, N, and O atoms for the synthesis of a variety of compounds. This account highlights the literature published since June 2018, completing previous reviews by the author.

摘要

使用二甲基甲酰胺（DMF）或二甲基乙酰胺（DMAc）作为反应物，会发生丰富多样的反应，这两种酰胺能够提供自身的 H、C、N 和 O 原子，用于合成各种化合物。本综述重点介绍了自 2018 年 6 月以来发表的文献，完成了作者之前的综述。

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本文引用的文献

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A copper(ii)-catalyzed annulative formylation of -alkynylanilines with DMF: a single-step strategy for 3-formyl indoles.铜（II）催化的邻炔基苯胺与DMF的环化甲酰化反应：一种合成3-甲酰基吲哚的单步策略
RSC Adv. 2018 Dec 7;8(71):40968-40973. doi: 10.1039/c8ra09214a. eCollection 2018 Dec 4.
2
Beyond a solvent: triple roles of dimethylformamide in organic chemistry.超越溶剂：二甲基甲酰胺在有机化学中的三重作用
RSC Adv. 2018 Aug 3;8(49):27832-27862. doi: 10.1039/c8ra04985h. eCollection 2018 Aug 2.
3
Direct synthesis of 2-oxo-acetamidines from methyl ketones, aromatic amines and DMF copper-catalyzed C(sp)-H amidination.
由甲基酮、芳香胺和DMF直接合成2-氧代脒——铜催化的C(sp)-H amidination反应
RSC Adv. 2019 Mar 4;9(13):7203-7209. doi: 10.1039/c9ra00616h. eCollection 2019 Mar 1.
4
Visible-light-promoted synthesis of secondary and tertiary thiocarbamates from thiosulfonates and -substituted formamides.可见光促进的硫代磺酸盐和取代甲酰胺合成仲和叔硫代氨基甲酸酯。
Org Biomol Chem. 2021 Oct 20;19(40):8701-8705. doi: 10.1039/d1ob01592c.
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Two C═C Bond Participation in Annulation to Pyridines Based on DMF as the Nonadjacent N and C Atom Donors.基于DMF作为非相邻氮和碳原子供体的两个碳-碳双键参与吡啶的环化反应。
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