Department of Organic Chemistry, Indian Institute of Science, Bangalore 560012, Karnataka, India.
Org Lett. 2020 Apr 17;22(8):2878-2882. doi: 10.1021/acs.orglett.0c00451. Epub 2020 Mar 31.
Rh(III)-catalyzed C-H activation and cyclization of sulfoxonium ylide with acrylates leads to an efficient synthesis of indanone derivatives. The reaction proceeds under mild and external metal-oxidant-free conditions. The sulfoxonium ylide acts as a traceless directing group as well as an internal oxidant. (4 + 1) Annulation after C-H activation leads to the formation of a carbocyclic ring, and the byproduct obtained is DMSO, which can be easily separated.
铑（III）催化的亚砜叶立德与丙烯酸盐的 C-H 活化和环化反应，高效合成了茚酮衍生物。反应在温和的、无需外加金属氧化剂的条件下进行。亚砜叶立德既是无痕迹导向基团，也是内部氧化剂。C-H 活化后的（4 + 1）环化反应导致了碳环的形成，得到的副产物是 DMSO，可容易分离。
