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姜黄素通过激活 Nrf2/HO-1 通路抑制人鼻成纤维细胞暴露于城市颗粒物所致的氧化应激。

Activation of the Nrf2/HO-1 pathway by curcumin inhibits oxidative stress in human nasal fibroblasts exposed to urban particulate matter.

机构信息

Department of Otorhinolaryngology-Head and Neck Surgery, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

Department of Otorhinolaryngology-Head and Neck Surgery, Eunpyeong St. Mary's Hospital, Seoul, Republic of Korea.

出版信息

BMC Complement Med Ther. 2020 Mar 30;20(1):101. doi: 10.1186/s12906-020-02886-8.

DOI:10.1186/s12906-020-02886-8
PMID:32228565
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7106591/
Abstract

BACKGROUND

Particulate matter (PM) can cause various negative acute and chronic diseases of the respiratory system, including the upper airways. Curcumin has been reported to have anti-inflammatory and anti-oxidative effects; therefore, we investigated the effects of curcumin on nasal fibroblasts exposed to urban PM (UPM).

METHODS

Samples of inferior turbinate tissue were obtained from six patients. Flow cytometry was used to assess the levels of reactive oxygen species (ROS) following the treatment of nasal fibroblasts with UPM and/or curcumin. We evaluated the effects of UPM and/or curcumin on the expression of phosphorylated ERK, Nrf2, HO-1, and SOD2 in fibroblasts by Western blotting.

RESULTS

When UPM was applied to nasal fibroblasts, ROS production was significantly increased in a dose-dependent manner. UPM-exposed fibroblasts caused the activation of ERK to increase HO-1 expression and decrease SOD2 expression. Treatment with curcumin reduced the UPM-mediated increase in ROS; this decrease in ROS occurred in a dose-dependent manner. The UPM-induced activation of ERK was inhibited by curcumin. Nrf2 production was also promoted to increase the expression of HO-1 and SOD2 by curcumin.

CONCLUSION

Curcumin reduced ROS production caused by UPM in human nasal fibroblasts in a dose-dependent manner, suggesting that curcumin has anti-oxidative effects and may be useful in the treatment of nasal diseases caused by UPM, such as allergic and chronic rhinitis.

摘要

背景

颗粒物（PM）可引起呼吸道的各种急、慢性负面疾病，包括上呼吸道。姜黄素具有抗炎和抗氧化作用；因此，我们研究了姜黄素对暴露于城市颗粒物（UPM）的鼻成纤维细胞的影响。

方法

从 6 名患者中获取下鼻甲组织样本。通过流式细胞术评估 UPM 和/或姜黄素处理鼻成纤维细胞后活性氧（ROS）的水平。我们通过 Western blot 评估 UPM 和/或姜黄素对成纤维细胞中磷酸化 ERK、Nrf2、HO-1 和 SOD2 表达的影响。

结果

当将 UPM 应用于鼻成纤维细胞时，ROS 的产生呈剂量依赖性显著增加。暴露于 UPM 的成纤维细胞导致 ERK 的激活增加 HO-1 的表达并降低 SOD2 的表达。用姜黄素处理可降低 UPM 介导的 ROS 增加；这种 ROS 的减少呈剂量依赖性。姜黄素抑制了 UPM 诱导的 ERK 激活。Nrf2 的产生也被促进，从而增加 HO-1 和 SOD2 的表达。

结论

姜黄素以剂量依赖性方式降低 UPM 在人鼻成纤维细胞中引起的 ROS 产生，表明姜黄素具有抗氧化作用，可能对治疗由 UPM 引起的鼻部疾病如过敏性和慢性鼻炎有用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1a2/7106591/2b5a210f49c2/12906_2020_2886_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1a2/7106591/ae55292299f2/12906_2020_2886_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1a2/7106591/456235f6ee49/12906_2020_2886_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1a2/7106591/7a9e0b0b85b2/12906_2020_2886_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1a2/7106591/dfc852d16d91/12906_2020_2886_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1a2/7106591/2b5a210f49c2/12906_2020_2886_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1a2/7106591/ae55292299f2/12906_2020_2886_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1a2/7106591/456235f6ee49/12906_2020_2886_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1a2/7106591/7a9e0b0b85b2/12906_2020_2886_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1a2/7106591/dfc852d16d91/12906_2020_2886_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1a2/7106591/2b5a210f49c2/12906_2020_2886_Fig5_HTML.jpg

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