Third Department of Psychiatry, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Department of Psychiatry, University of California, San Diego, California, USA.
CNS Spectr. 2021 Aug;26(4):326-332. doi: 10.1017/S1092852920000139. Epub 2020 Mar 31.
"Precision medicine" and "personalized medicine" constitute goals of research since antiquity and this was intensified with the arrival of the "evidence-based medicine." precision and personalized psychiatry (3P) when achieved will constitute a radical shift in our paradigm and it will be even more transformative than in other fields of medicine. The biggest problems so far are the problematic definition of mental disorder, available treatments seem to concern broad categories rather than specific disorders and finally clinical predictors of treatment response or side effects and biological markers do not exist. Precision and personalized psychiatry like all precision medicine will be a laborious and costly task; thus the partnership of scientists with industry and the commercialization of new methods and technologies will be an important element for success. The development of an appropriate legal framework which will both support development and progress but also will protect the rights and the privacy of patients and their families is essential.
“精准医学”和“个性化医学”是自古以来医学研究的目标，而随着“循证医学”的到来，这一目标得到了加强。精准和个性化精神病学（3P）一旦实现，将彻底改变我们的范式，其变革程度将超过医学的其他领域。迄今为止，最大的问题是精神障碍的定义存在问题，现有的治疗方法似乎涉及广泛的类别，而不是特定的疾病，最后，治疗反应或副作用的临床预测因子和生物标志物并不存在。精准和个性化精神病学与所有精准医学一样，将是一项艰巨而昂贵的任务；因此，科学家与行业合作，以及新方法和技术的商业化，将是成功的重要因素。制定一个适当的法律框架是至关重要的，这个框架既要支持发展和进步，也要保护患者及其家属的权利和隐私。
