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用胺和铵烷基链、树枝状大分子和树枝状聚合物对二氧化硅进行功能化:合成与抗菌性能。

Functionalization of silica with amine and ammonium alkyl chains, dendrons and dendrimers: Synthesis and antibacterial properties.

机构信息

Department of Química Orgánica y Química Inorgánica, Instituto de Investigación Química "Andrés M. del Río" (IQAR), Campus Universitario, Universidad de Alcalá (UAH), E-28805 Alcalá de Henares, Madrid, Spain; Networking Research Center for Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Spain; Institute Ramón y Cajal for Health Research (IRYCIS), Spain.

Department of Biomedicina y Biotecnología, Facultad de Farmacia, Universidad de Alcalá (UAH), E-28805 Alcalá de Henares, Madrid, Spain.

出版信息

Mater Sci Eng C Mater Biol Appl. 2020 Apr;109:110526. doi: 10.1016/j.msec.2019.110526. Epub 2019 Dec 20.

Abstract

Materials modified with ammonium groups on the surface have shown antibacterial activity. In this paper, alkyl chains, carbosilane (CBS) dendrimers and dendrons and poly(amidoamine) (PAMAM) dendrimers containing amine and ammonium groups have been grafted to silica surface and the influence of molecule structure on the stability and on antibacterial activity have been evaluated. These materials have been characterized by thermogravimetric analysis (TGA), zeta (Z) potential, scanning electron microscopy (SEM), infrared spectroscopy (IR) and nuclear magnetic resonance (C CP MAS NMR). The degree of silica functionalization depends on type of outer groups, amine or ammonium, type and core of dendrimer, and length of chains. The Z potential measurements of these materials in water suspensions were used to test their stability in this medium. These measurements showed, for some of the modified silicas, the diminishing of Z potential from positive values toward zero, probably due to interaction of the functional groups with the silica surface. This variation was also dependent on ligand structure and peripheral functions. Finally, studies of inhibition of bacteria growth stand out again the relevance of ligand structure and number of functional groups on silica surface. The most active systems were those with more surface covered, those with cationic groups further away from silica surface and higher dendritic generation.

摘要

表面带有铵基团的材料已显示出抗菌活性。在本文中,已将烷基链、碳硅烷(CBS)树枝状大分子和支化聚合物以及含有胺和铵基团的聚(酰胺-胺)(PAMAM)树枝状大分子接枝到硅烷表面,并评估了分子结构对稳定性和抗菌活性的影响。这些材料已通过热重分析(TGA)、Zeta(Z)电位、扫描电子显微镜(SEM)、红外光谱(IR)和固态核磁共振(C CP MAS NMR)进行了表征。硅烷的功能化程度取决于外基团的类型、胺或铵、树枝状大分子的类型和核心以及链的长度。这些材料在水悬浮液中的 Z 电位测量用于测试它们在该介质中的稳定性。这些测量结果表明,对于一些改性的硅,Z 电位从正值向零减小,这可能是由于官能团与硅烷表面的相互作用。这种变化也取决于配体结构和外围功能。最后,细菌生长抑制的研究再次突出了配体结构和硅表面上官能团数量的重要性。最活跃的系统是那些表面覆盖更多、带有正电荷基团且与硅烷表面距离更远以及具有更高支化度的系统。

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