带有阳离子碳硅烷树枝状分子的树枝状银和金纳米颗粒的抗菌和抗真菌特性
Antibacterial and antifungal properties of dendronized silver and gold nanoparticles with cationic carbosilane dendrons.
作者信息
Peña-González Cornelia E, Pedziwiatr-Werbicka Elzbieta, Martín-Pérez Tania, Szewczyk Eligia M, Copa-Patiño José L, Soliveri Juan, Pérez-Serrano Jorge, Gómez Rafael, Bryszewska Maria, Sánchez-Nieves Javier, de la Mata F Javier
机构信息
Dpto. de Química Orgánica y Química Inorgánica, Universidad de Alcalá, Campus Universitario, E-28871 Alcalá de Henares, Madrid, Spain; Networking Research Center for Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Spain.
Department of General Biophysics, Faculty of Biology and Environmental Protection, University of Lodz, 141/143 Pomorska Street, 90-236 Lodz, Poland.
出版信息
Int J Pharm. 2017 Aug 7;528(1-2):55-61. doi: 10.1016/j.ijpharm.2017.05.067. Epub 2017 May 31.
Water soluble silver nanoparticles (AgNPs) capped with cationic carbosilane dendrons have been synthesized by direct reaction in water of dendrons, silver precursor and a reducing agent. These nanoparticles have been characterized by nuclear magnetic resonance (NMR), transmission electron microscopy (TEM), dynamic light scattering (DLS), thermogravimetric analysis (TGA), ultraviolet spectroscopy (UV), elemental analysis, and zeta potential (ZP). The antibacterial and antifungal properties of the cationic dendrons and dendronized AgNPs and AuNPs with these dendrons have been evaluated against Gram-negative and Gram-positive bacterial -including resistant strains- and yeast strains, respectively. The results stand out for the activity of AgNPs covered with first generation dendron compared with this free dendron and corresponding dendronized AuNPs.
通过在水中将树枝状分子、银前驱体和还原剂直接反应，合成了用阳离子碳硅烷树枝状分子包覆的水溶性银纳米颗粒（AgNPs）。这些纳米颗粒已通过核磁共振（NMR）、透射电子显微镜（TEM）、动态光散射（DLS）、热重分析（TGA）、紫外光谱（UV）、元素分析和zeta电位（ZP）进行了表征。分别针对革兰氏阴性菌和革兰氏阳性菌（包括耐药菌株）以及酵母菌株，评估了阳离子树枝状分子以及带有这些树枝状分子的树枝状化AgNPs和AuNPs的抗菌和抗真菌性能。与游离树枝状分子和相应的树枝状化AuNPs相比，第一代树枝状分子包覆的AgNPs的活性尤为突出。
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