铈掺杂磁铁矿纳米粒子通过化学发光法检测甲硝唑的高灵敏度检测。
Cerium doped magnetite nanoparticles for highly sensitive detection of metronidazole via chemiluminescence assay.
机构信息
College of Materials Science and Engineering, Nanjing Forestry University, No. 159, Longpan Road, Nanjing, 210037, Jiangsu, People's Republic of China; Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, Nanjing Forestry University, Nanjing 210037, China.
Research Laboratory of Advanced Water and Wastewater Treatment Processes, Department of Applied Chemistry, Faculty of Chemistry, University of Tabriz, 51666-16471 Tabriz, Iran.
出版信息
Spectrochim Acta A Mol Biomol Spectrosc. 2020 Jun 15;234:118272. doi: 10.1016/j.saa.2020.118272. Epub 2020 Mar 17.
Cerium doped magnetite nanoparticle (CDM) was synthesized via a co-precipitation method and used as the co-reactant of luminol-KFe(CN) chemiluminescent system. The physical-chemical features of CDM were studied by XPS, XRD, HRTEM, FESEM, VSM, BET, and FTIR analyses. This simple and highly sensitive nanoprobe enabled the determination of minor concentrations of metronidazole (MNZ). Owing to the quenching efficacy of MNZ in the studied chemiluminescence system, a linear range of 3.47 × 10-9.37 × 10 mol/L was obtained with a limit of detection of 3.91 × 10 mol/L. This biosensor was used for MNZ detection in human serum samples, which was highly efficient. The outcomes of this study give credit to the proposed biosensor to be applied for detection of MNZ in biological samples.
铈掺杂磁铁矿纳米粒子（CDM）通过共沉淀法合成，并用作鲁米诺-KFe（CN）化学发光体系的共反应物。通过 XPS、XRD、HRTEM、FESEM、VSM、BET 和 FTIR 分析研究了 CDM 的物理化学性质。这种简单且高灵敏的纳米探针能够测定甲硝唑（MNZ）的低浓度。由于 MNZ 在研究的化学发光体系中具有猝灭效果，因此获得了 3.47×10-9.37×10 mol/L 的线性范围和 3.91×10 mol/L 的检测限。该生物传感器用于人血清样品中 MNZ 的检测，效率很高。该研究结果证明，所提出的生物传感器可用于生物样品中 MNZ 的检测。
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