Functional Foods Research Group, University of Southern Queensland, Toowoomba, QLD 4350, Australia.
School of Health and Wellbeing, University of Southern Queensland, Toowoomba, QLD 4350, Australia.
Nutrients. 2020 Mar 27;12(4):931. doi: 10.3390/nu12040931.
Saskatoon berry () is a potential functional food containing anthocyanins and flavonols, as well as ellagitannins and phenolic acids. We have determined the potential therapeutic effects of Saskatoon berry in diet-induced metabolic syndrome. Nine- to ten-week-old male Wistar rats were randomly assigned to four groups. Two groups were fed on control diets, either corn starch (C) or high-carbohydrate, high-fat diet (H) respectively, for 16 weeks. Two further groups were fed on C or H diet for 16 weeks with Saskatoon berry powder added to the diet for the final 8 weeks (CSSK, HSSK). After 16 weeks, H rats showed symptoms of metabolic syndrome, including increased body weight, visceral adiposity, systolic blood pressure, cardiac fibrosis, plasma concentrations of triglycerides and non-esterified fatty acids, and plasma activities of alanine transaminase and aspartate transaminase. Saskatoon berry intervention normalised body weight and adiposity, improved glucose tolerance, decreased systolic blood pressure, improved heart and liver structure and function with decreased infiltration of inflammatory cells, and decreased plasma total cholesterol. Further, Saskatoon berry normalised liver expression of hexokinase 1 and glycogen phosphorylase and increased glucose 6-phosphatase relative to H rats. These results suggest that Saskatoon berry regulates glycolysis, gluconeogenesis and glycogenesis to improve metabolic syndrome.
萨斯卡通莓（ ）是一种含有花青素和类黄酮，以及鞣花单宁和酚酸的潜在功能性食品。我们已经确定了萨斯卡通莓在饮食诱导的代谢综合征中的潜在治疗作用。9 至 10 周龄雄性 Wistar 大鼠被随机分为四组。两组分别喂食对照饮食，即玉米淀粉（C）或高碳水化合物高脂肪饮食（H），共 16 周。另外两组分别喂食 C 或 H 饮食 16 周，最后 8 周添加萨斯卡通莓粉（CSSK、HSSK）。16 周后，H 组大鼠出现代谢综合征症状，包括体重增加、内脏肥胖、收缩压、心脏纤维化、甘油三酯和非酯化脂肪酸的血浆浓度以及丙氨酸转氨酶和天冬氨酸转氨酶的血浆活性升高。萨斯卡通莓干预使体重和肥胖正常化，改善葡萄糖耐量，降低收缩压，改善心脏和肝脏结构和功能，减少炎症细胞浸润，降低总胆固醇的血浆浓度。此外，萨斯卡通莓使肝脏中己糖激酶 1 和糖原磷酸化酶的表达正常化，并使相对于 H 组的葡萄糖 6-磷酸酶增加。这些结果表明，萨斯卡通莓通过调节糖酵解、糖异生和糖生成来改善代谢综合征。
