功能性中枢神经系统疾病的神经心理学评估。I. 精神分裂症和情感性疾病中的半球功能特征。

Neuropsychological assessment of functional central nervous system disorders. I. Hemispheric functioning characteristics in schizophrenia and affective illness.

作者信息

Bellini L, Gambini O, Palladino F, Scarone S

机构信息

Department of Psychiatry, University of Milan Medical School, Italy.

出版信息

Acta Psychiatr Scand. 1988 Aug;78(2):242-6. doi: 10.1111/j.1600-0447.1988.tb06331.x.

DOI:10.1111/j.1600-0447.1988.tb06331.x

PMID:3223323

Abstract

The neuropsychological characteristics of a group of schizophrenic and affective patients were assessed by mean of a comprehensive neuropsychological tool, the Luria-Nebraska Neuropsychological Batter (LNNB), to determine the lateralized hemispheric neurofunctional characteristics in major functional central nervous system disorders. The results showed that schizophrenics had more right-hemisphere impairment than affectives. They do not substantiate the hypothesis of right hemisphere-lateralized malfunctioning in functional mood disorders. Psychopharmacological treatment influences neuropsychological test performance, neuroleptics having the greatest effects. Pharmacological effects other than anticholinergic ones are responsible for the negative influence on neuropsychological test performance.

摘要

通过一种综合性神经心理学工具——鲁利亚-内布拉斯加神经心理成套测验（LNNB），对一组精神分裂症患者和情感障碍患者的神经心理学特征进行了评估，以确定主要功能性中枢神经系统疾病中大脑半球的神经功能特征。结果显示，精神分裂症患者比情感障碍患者有更多的右半球损伤。这些结果并不支持功能性情绪障碍中右半球功能失调的假说。精神药物治疗会影响神经心理学测试表现，其中抗精神病药物的影响最大。除抗胆碱能药物外的其他药理作用是对神经心理学测试表现产生负面影响的原因。