Faustman W O, Moses J A, Csernansky J G
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, CA.
Psychiatry Res. 1988 Oct;26(1):29-34. doi: 10.1016/0165-1781(88)90084-4.
Recent attempts at subgrouping schizophrenia have emphasized negative symptoms (e.g., blunted affect, emotional withdrawal), and several works have suggested that patients with negative symptoms show greater cognitive deficits and structural brain abnormalities. However, many of these studies have relied on screening devices or single measures of neuropsychological performance. Accordingly, the present study used the Luria-Nebraska Neuropsychological Battery (LNNB) in assessing 38 unmedicated inpatients with a diagnosis of schizophrenia. The results found no relationship between LNNB performance and symptom ratings derived from clinical interviews using the Brief Psychiatric Rating Scale. The findings show that cognitive performance may be unrelated to symptomatology when a complex battery type test is used.
近期对精神分裂症进行亚组划分的尝试着重于阴性症状（如情感迟钝、情感退缩），并且有多项研究表明，有阴性症状的患者表现出更严重的认知缺陷和脑结构异常。然而，这些研究中有许多都依赖于筛查工具或神经心理学表现的单一测量方法。因此，本研究使用鲁利亚-内布拉斯加神经心理成套测验（LNNB）对38名诊断为精神分裂症的未服药住院患者进行评估。结果发现，LNNB表现与使用简明精神病评定量表从临床访谈中得出的症状评分之间没有关系。研究结果表明，当使用综合成套测验类型的测试时，认知表现可能与症状学无关。
