Miller L S, Swanson-Green T, Moses J A, Faustman W O
Department of Psychology, University of Georgia, Athens 30602-3013, USA.
J Psychiatr Res. 1996 Jul-Aug;30(4):277-82. doi: 10.1016/0022-3956(96)00013-1.
Controversy continues regarding the differential diagnostic distinction between schizoaffective disorder and schizophrenia, and there are few published studies that examine the neuropsychological performance of schizoaffective patients. We evaluated 52 RDC-diagnosed schizophrenic and schizoaffective patients with equal numbers of medicated and unmedicated patients using the Luria-Nebraska Neuropsychological Battery and additional cognitive measures. Both groups performed at cognitively impaired levels. The cognitive performance level of schizoaffective patients was indistinguishable from that of the schizophrenic patients. The RDC subtype of schizoaffective disorder (depressed or manic) also was not related to cognitive performance level. Findings are consistent with the notion that cognitive impairment is found in a significant portion of schizophrenic (and possibly schizoaffective) patients and that the presence of this deficit may characterize a specific subgroup of patients.
关于分裂情感性障碍和精神分裂症之间的鉴别诊断仍存在争议，而且很少有已发表的研究考察分裂情感性障碍患者的神经心理学表现。我们使用鲁利亚-内布拉斯加神经心理成套测验及其他认知测量方法，对52例经研究诊断标准（RDC）诊断的精神分裂症和分裂情感性障碍患者进行了评估，其中药物治疗和未药物治疗的患者数量相等。两组患者的认知水平均受损。分裂情感性障碍患者的认知表现水平与精神分裂症患者并无差异。分裂情感性障碍的RDC亚型（抑郁型或躁狂型）也与认知表现水平无关。研究结果与以下观点一致，即相当一部分精神分裂症（可能还有分裂情感性障碍）患者存在认知障碍，而且这种缺陷的存在可能是特定患者亚组的特征。
