Sasanfar Bahareh, Toorang Fatemeh, Maleki Farzad, Esmaillzadeh Ahmad, Zendehdel Kazem
Cancer Research Center, Cancer Institute of Iran, Tehran University of Medical Sciences, Tehran, Iran.
Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
Public Health Nutr. 2021 Apr;24(5):965-972. doi: 10.1017/S1368980019004397. Epub 2020 Apr 1.
The aim of this study was to determine the relationship between dietary total antioxidant capacity (dTAC) and risk of breast cancer among Iranian women.
In this hospital-based case-control study, dietary intake of participants was collected using a 168-item validated FFQ. Dietary TAC was assessed using FRAP assay considering. Logistic regression was used to obtain ORs for breast cancer across quartiles of dTAC.
Cancer Institute, Iran.
We included 412 women with pathologically confirmed breast cancer and 456 apparently healthy controls.
Mean dTAC was 11·3 ± 5·8 for cases and 12·1 ± 7·9 for controls. A trend towards significant inverse association was seen between dTAC and odds of breast cancer in the whole population; such that after controlling for several potential confounders, individuals in the highest quartile of dTAC were 0·39 times less likely to have breast cancer than those in the lowest quartile (0·61; 95 % CI: 0·38, 0·99, P < 0·05). In the stratified analysis by menopausal status, we found that postmenopausal women with the greatest dTAC had lower odds for breast cancer, compared with those with the lowest dTAC (0·47; 95 % CI: 0·24, 0·93, P < 0·05). This association strengthened after additional adjustment for BMI (0·28; 95 % CI: 0·11, 0·72, P < 0·05). No significant association was seen between dTAC and odds of breast cancer in premenopausal women.
We found that dietary TAC was inversely associated with risk of breast cancer, in particular among postmenopausal women. Prospective cohort studies are needed to confirm these findings.
本研究旨在确定伊朗女性饮食总抗氧化能力（dTAC）与乳腺癌风险之间的关系。
在这项基于医院的病例对照研究中，采用经过验证的包含168个条目的食物频率问卷（FFQ）收集参与者的饮食摄入量。使用铁离子还原抗氧化能力（FRAP）测定法评估饮食TAC。采用逻辑回归分析得出dTAC四分位数水平上乳腺癌的比值比（OR）。
伊朗癌症研究所。
我们纳入了412例经病理确诊的乳腺癌女性患者和456名明显健康的对照者。
病例组的平均dTAC为11.3±5.8，对照组为12.1±7.9。在整个人群中，dTAC与乳腺癌发病几率之间存在显著负相关趋势；在控制了几个潜在混杂因素后，dTAC最高四分位数组的个体患乳腺癌的可能性比最低四分位数组低0.39倍（0.61；95%可信区间：0.38，0.99，P<0.05）。在按绝经状态分层分析中，我们发现dTAC最高的绝经后女性患乳腺癌的几率低于dTAC最低的女性（0.47；95%可信区间：0.24，0.93，P<0.05）。在进一步调整体重指数（BMI）后，这种关联得到加强（0.28；95%可信区间：0.11，0.72，P<0.05）。在绝经前女性中，未发现dTAC与乳腺癌发病几率之间存在显著关联。
我们发现饮食TAC与乳腺癌风险呈负相关，尤其是在绝经后女性中。需要进行前瞻性队列研究来证实这些发现。
