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骶髂关节疼痛经冷射频去神经治疗后阿片类药物摄入量的减少:长达1年的回顾性评估

Reduction of opioid intake after cooled radiofrequency denervation for sacroiliac joint pain: a retrospective evaluation up to 1 year.

作者信息

Tinnirello Andrea

机构信息

Anesthesiology and Pain Management Unit, Azienda Socio Sanitaria Territoriale della Franciacorta, Brescia, Italy.

出版信息

Korean J Pain. 2020 Apr 1;33(2):183-191. doi: 10.3344/kjp.2020.33.2.183.

Abstract

BACKGROUND

Opioids can present intolerable adverse side-effects to patients who use these analgesics to mitigate chronic pain. In this retrospective analysis, cooled radiofrequency (CRF) denervation was evaluated to provide pain and disability relief and reduce opioid use in patients with sacroiliac joint (SIJ) derived low back pain (LBP).

METHODS

Twenty-seven patients with pain from SIJ refractory to conservative treatments, and taking opioids chronically (> 3 mo), were included. Numeric rating scale (NRS) and Oswestry disability index (ODI) scores were collected at 1, 6, and 12 months post-procedure. Opioid use between baseline and each follow-up visit was compared for the entire group and for those who experienced successful (pain reduction ≥ 50% of baseline value) or unsuccessful CRF denervation.

RESULTS

Severe initial mean pain (NRS score: 7.7 ± 1.0) and disability (ODI score: 50.1 ± 9.0), and median opioid use (morphine equivalent daily dose: 40 ± 37 mg) were significantly reduced up to 12 months post-intervention. CRF denervation was successful in 44.4% of the patients at 12 months. Regardless of procedure success, patients demonstrated similar opioid reductions and changes in opioid use at 12 months. Two patients (7.4%) experienced neuritis following CRF denervation.

CONCLUSIONS

CRF denervation of the SIJ can safely elicit pain and disability relief, and reduce opioid use, regardless of intervention success. Future studies may support CRF denervation as a dependable therapy to alleviate opioid use in patients with SIJ-derived LBP and show that opioid use measurements can be a surrogate indicator of pain.

摘要

背景

阿片类药物可能会给使用这些镇痛药缓解慢性疼痛的患者带来难以忍受的不良副作用。在这项回顾性分析中,评估了冷射频(CRF)去神经术,以缓解骶髂关节(SIJ)源性下腰痛(LBP)患者的疼痛和残疾状况,并减少阿片类药物的使用。

方法

纳入27例经保守治疗后SIJ疼痛仍难缓解且长期(>3个月)服用阿片类药物的患者。在术后1、6和12个月收集数字评分量表(NRS)和Oswestry功能障碍指数(ODI)评分。比较整个研究组以及CRF去神经术成功(疼痛减轻≥基线值的50%)或失败的患者在基线和每次随访时的阿片类药物使用情况。

结果

干预后长达12个月,患者的初始重度平均疼痛(NRS评分:7.7±1.0)、残疾程度(ODI评分:50.1±9.0)以及阿片类药物使用中位数(吗啡当量日剂量:40±37mg)均显著降低。12个月时,44.4%的患者CRF去神经术成功。无论手术是否成功,患者在12个月时的阿片类药物减少量和使用变化情况相似。2例患者(7.4%)在CRF去神经术后出现神经炎。

结论

SIJ的CRF去神经术能够安全地缓解疼痛和残疾状况,并减少阿片类药物的使用,无论干预是否成功。未来的研究可能会支持将CRF去神经术作为一种可靠的治疗方法,以减轻SIJ源性LBP患者的阿片类药物使用,并表明阿片类药物使用测量可作为疼痛的替代指标。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b0f/7136294/7b6629b2b620/KJP-33-183-f1.jpg

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