Center of Marine Sciences, CCMAR, Gambelas Campus, University of Algarve, UAlg, 8005-139 Faro, Portugal.
Department of Chemistry and Pharmacy, Faculty of Sciences and Technology, FCT, Gambelas Campus, University of Algarve, UAlg, 8005-139 Faro, Portugal.
Molecules. 2020 Mar 30;25(7):1574. doi: 10.3390/molecules25071574.
Toxoplasmosis is an infectious disease with paramount impact worldwide, affecting many vulnerable populations and representing a significant matter of concern. Current therapies used against toxoplasmosis are based essentially on old chemotypes, which fail in providing a definitive cure for the disease, placing the most sensitive populations at risk for irreversible damage in vital organs, culminating in death in the most serious cases. Antimalarial drugs have been shown to possess key features for drug repurposing, finding application in the treatment of other parasite-borne illnesses, including toxoplasmosis. Antimalarials provide the most effective therapeutic solutions against toxoplasmosis and make up for the majority of currently available antitoxoplasmic drugs. Additionally, other antiplasmodial drugs have been scrutinized and many promising candidates have emanated in recent developments. Available data demonstrate that it is worthwhile to explore the activity of classical and most recent antimalarial chemotypes, such as quinolines, endoperoxides, pyrazolo[1,5-]pyrimidines, and nature-derived peptide-based parasiticidal agents, in the context of toxoplasmosis chemotherapy, in the quest for encountering more effective and safer tools for toxoplasmosis control or eradication.
弓形虫病是一种具有全球重要影响的传染病，影响许多弱势群体，是一个重大关切问题。目前用于治疗弓形虫病的疗法主要基于旧的化学类型，这些疗法未能提供疾病的明确治愈方法，使最敏感的人群面临重要器官不可逆损伤的风险，在最严重的情况下导致死亡。抗疟药物已被证明具有药物再利用的关键特征，可用于治疗其他寄生虫病，包括弓形虫病。抗疟药物是治疗弓形虫病最有效的治疗方法，构成了目前可用的抗弓形虫药物的大部分。此外，其他抗疟药物也受到了关注，最近的发展中涌现出许多有前途的候选药物。现有数据表明，值得探索经典和最新的抗疟化学类型的活性，如喹啉类、过氧化物、吡唑并[1,5-]嘧啶类和基于天然的肽类寄生虫杀伤剂，以寻找更有效和更安全的弓形虫病控制或根除工具。
