Tan Sijie, Tong Wen Han, Vyas Ajai
School of Biological Sciences, Nanyang Technological University, Singapore, Singapore.
Front Nutr. 2022 Feb 25;9:827286. doi: 10.3389/fnut.2022.827286. eCollection 2022.
is an obligate intracellular parasite that mainly infects warm-blooded animals including humans. can encyst and persist chronically in the brain, leading to a broad spectrum of neurological sequelae. Despite the associated health threats, no clinical drug is currently available to eliminate cysts. In a continuous effort to uncover novel therapeutic agents for these cysts, the potential of nutritional products has been explored. Herein, we describe findings from and studies that support the efficacy of plant-based foods and nutraceuticals against brain cyst burden and cerebral pathologies associated with chronic toxoplasmosis. Finally, we discuss strategies to increase the translatability of preclinical studies and nutritional products to address whether nutritional therapy can be beneficial for coping with chronic infections in humans.
是一种专性细胞内寄生虫，主要感染包括人类在内的温血动物。它可在大脑中形成包囊并长期存在，导致广泛的神经后遗症。尽管存在相关健康威胁，但目前尚无临床药物可消除包囊。为了不断寻找针对这些包囊的新型治疗药物，人们探索了营养产品的潜力。在此，我们描述了[具体研究]和[具体研究]的结果，这些结果支持植物性食物和营养保健品对慢性弓形虫病相关的脑包囊负担和脑部病变的疗效。最后，我们讨论了提高临床前研究和营养产品可转化性的策略，以探讨营养疗法是否有助于应对人类的慢性[寄生虫名称]感染。
