Optimal Body Mass Index Cut-off Point for Predicting Colorectal Cancer Survival in an Asian Population: A National Health Information Database Analysis.

The optimal body mass index (BMI) range for predicting survival in Asian colorectal cancer patients is unknown. We established the most appropriate cut-off point of BMI to predict better survival in Asian colorectal cancer patients using a two-stage approach. Two cohorts of colorectal cancer patients were included in this study: 5815 hospital-based development cohort and 54,043 nationwide validation cohort. To determine the optimal BMI cut-off point at diagnosis, the method of Contal and O'Quigley was used. We evaluated the association between BMI and overall survival (OS) using the Cox proportional hazard model. During a median follow-up of 5.7 and 5.1 years for the development and the validation cohort, 1180 (20.3%) and 10,244 (19.0%) deaths occurred, respectively. The optimal cut-off of BMI identified as 20.2 kg/m ( < 8.0 × 10) for differentiating between poorer and better OS in the development cohort. When compared to the patients with a BMI < 20.2 kg/m, the patients with a BMI ≥ 20.2 kg/m had a significantly better OS (HR = 0.62, 95% CI = 0.54-0.72, = 1.1 × 10). The association was validated in the nationwide cohort, showing better OS in patients with a BMI ≥ 20.2 kg/m (HR = 0.64, 95% CI = 0.60-0.67, < 0.01). We suggest the use of a BMI value of 20.2 kg/m to predict survival in Asian colorectal cancer patients.