Shirazi Mahboobeh, Khodakarami Fatemeh, Feizabad Elham, Ghaemi Marjan
Maternal, Fetal & Neonatal Research Centre, Tehran University of Medical Sciences, Tehran, Iran.
Health Reproductive Research Centre, Tehran University of Medical Sciences, Tehran, Iran.
Endocrine. 2020 Jul;69(1):49-52. doi: 10.1007/s12020-020-02265-w. Epub 2020 Mar 31.
This study aimed to compare the nigella sativa vs. placebo effect on anthropometric and biochemical indices in postmenopausal women with metabolic syndrome.
This randomized, double-blinded, placebo-controlled trial was conducted as a third-phase trial among 140 menopausal women within the age of 45-60 years old, who were suffering from metabolic syndrome and were assigned to receive 500 mg nigella sativa or placebo pill once daily. Anthropometric and biochemical parameters including body weight, waist circumference, serum lipid profile, fasting blood sugar, and HbA1C were measured at baseline and 8 weeks after administration the ingredient or placebo.
In nigella sativa group, the serum markers such as low-density lipoprotein (115.1 ± 17.6 vs. 127.7 ± 12.6), triglyceride (158.3 ± 14.0 vs. 166.7 ± 16.0), total cholesterol (115.1 ± 17.6 vs. 127.7 ± 12.6), and fasting blood sugar (90.8 ± 16.9 vs. 113.7 ± 12.1) decreased significantly compared with the placebo (p < 0.001).
Administration of nigella sativa might be recommended for improving lipid profile and blood sugar in postmenopausal women with the metabolic syndrome.
本研究旨在比较黑种草籽与安慰剂对患有代谢综合征的绝经后女性人体测量和生化指标的影响。
本随机、双盲、安慰剂对照试验作为第三阶段试验，在140名年龄在45 - 60岁之间患有代谢综合征的绝经后女性中进行，她们被分配每天服用500毫克黑种草籽或安慰剂药丸。在基线以及服用成分或安慰剂8周后，测量人体测量和生化参数，包括体重、腰围、血脂谱、空腹血糖和糖化血红蛋白。
在黑种草籽组中，与安慰剂相比，血清标志物如低密度脂蛋白（115.1±17.6对127.7±12.6）、甘油三酯（158.3±14.0对166.7±16.0）、总胆固醇（115.1±17.6对127.7±12.6）和空腹血糖（90.8±16.9对113.7±12.1）显著降低（p<0.001）。
对于患有代谢综合征的绝经后女性，建议使用黑种草籽来改善血脂谱和血糖。
