印度加尔各答环境源中霍乱弧菌非O1型的毒素谱
Toxin profiles of Vibrio cholerae non-O1 from environmental sources in Calcutta, India.
作者信息
Nair G B, Oku Y, Takeda Y, Ghosh A, Ghosh R K, Chattopadhyay S, Pal S C, Kaper J B, Takeda T
机构信息
National Institute of Cholera and Enteric Diseases, Calcutta, India.
出版信息
Appl Environ Microbiol. 1988 Dec;54(12):3180-2. doi: 10.1128/aem.54.12.3180-3182.1988.
Abstract
A collection of Vibrio cholerae non-O1 isolated from the aquatic environs of Calcutta, a cholera-hyperendemic area, were examined for the production of cholera toxin (CT), Shiga-like toxins (Vero toxins), heat-stable enterotoxin, and hemolysins. Two (0.5%) V. cholerae non-O1 isolates produced CT. The DNA from both these isolates also hybridized with a DNA probe containing sequences encoding the A subunit of CT. None of the strains produced Shiga-like toxins or heat-stable enterotoxin. Hemolytic activity was observed in 89.7% of the strains, of which 36.1% exhibited biological activity in the suckling mouse. However, none of them produced a hemolysin that cross-reacted with the thermostable direct hemolysin of Vibrio parahaemolyticus. It appears from this study that a small percentage of environmental V. cholerae non-O1 strains do possess the potential for causing cholera-like diarrhea.
摘要
从霍乱高发地区加尔各答的水生环境中分离出一批霍乱弧菌非O1菌株，检测它们是否产生霍乱毒素（CT）、志贺样毒素（Vero毒素）、热稳定肠毒素和溶血素。两株（0.5%）霍乱弧菌非O1菌株产生了CT。这两株菌株的DNA也与包含编码CT A亚基序列的DNA探针杂交。所有菌株均未产生志贺样毒素或热稳定肠毒素。89.7%的菌株观察到溶血活性，其中36.1%在乳鼠中表现出生物活性。然而，它们均未产生与副溶血性弧菌耐热直接溶血素发生交叉反应的溶血素。这项研究表明，一小部分环境中的霍乱弧菌非O1菌株确实具有引起霍乱样腹泻的潜力。
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