Itahashi K, Inaba N, Fukazawa I, Takamizawa H
Division of Obstetrics and Gynecology, Hospital of Kawasaki Steel Corporation Health Insurance Society, Chiba, Japan.
Arch Gynecol Obstet. 1988;243(4):191-7. doi: 10.1007/BF00932267.
Using conventional radioimmunoassay kits, we measured concentrations of two cancer-related antigens, tissue polypeptide antigen (TPA) and cancer antigen 125 (CA125) throughout gestation and at delivery. The maternal serum was collected from 147 pregnant women between 5 and 43 weeks gestation and 27 women were studied at delivery at which time samples of maternal blood, umbilical artery and vein blood as well as amniotic fluid were collected. The various concentrations of TPA and CA125 were compared with placental weight and infant birth weight. The results are summarized as follows: (1) Mean TPA levels in maternal serum increased with advancing gestation and rose above 110 U/l (upper non-pregnant limit) from 35 weeks onwards. Mean CA125 levels rose above 35 U/ml (normal non-pregnant upper limit) before 9 weeks gestation and thereafter fell. Both levels were markedly raised immediately after delivery. (2) In umbilical artery and vein serum, mean TPA levels were slightly raised. However, there were no significant differences between TPA levels in maternal serum and matched serum from the umbilical artery and vein. Mean umbilical CA125 levels were below 35 U/ml, while mean CA125 levels were significantly higher in the corresponding maternal serum. (3) The concentrations of TPA and CA125 were extremely high in amniotic fluid. The mean values reached 3604 U/l and 2187 U/ml, respectively. (4) None of the concentrations of TPA and CA125 in those pregnancy-related body fluids correlated significantly with birth weight, placental weight or fetal sex. These findings suggest that the production of these two cancer-related antigens is not by the fetus but the placenta.
我们使用传统的放射免疫分析试剂盒，在整个孕期及分娩时测量了两种癌症相关抗原——组织多肽抗原（TPA）和癌抗原125（CA125）的浓度。从147名妊娠5至43周的孕妇中采集母血血清，并对27名分娩时的妇女进行研究，此时采集母血、脐动脉和脐静脉血以及羊水样本。将TPA和CA125的不同浓度与胎盘重量和婴儿出生体重进行比较。结果总结如下：（1）母血血清中TPA的平均水平随孕周增加而升高，从35周起升至110 U/l以上（非孕期上限）。CA125的平均水平在妊娠9周前升至35 U/ml以上（非孕期正常上限），此后下降。分娩后这两种水平均显著升高。（2）在脐动脉和脐静脉血清中，TPA的平均水平略有升高。然而，母血血清与脐动脉和脐静脉匹配血清中的TPA水平无显著差异。脐部CA125的平均水平低于35 U/ml，而相应母血血清中的CA125平均水平显著更高。（3）羊水中TPA和CA125的浓度极高。平均值分别达到3604 U/l和2187 U/ml。（4）这些与妊娠相关体液中TPA和CA125的浓度均与出生体重、胎盘重量或胎儿性别无显著相关性。这些发现表明，这两种癌症相关抗原不是由胎儿而是由胎盘产生的。
