孕期CA 125抗原的个体发生：羊水的免疫放射测定及胎膜的免疫组织化学定位

Ontogeny of CA 125 antigen in pregnancy: immunoradiometric determination in amniotic fluid and immunohistochemical localization in fetal membranes.

作者信息

Barbati A, Anceschi M M, Alberti P, Pomili G, Di Renzo G C, Cosmi E V

机构信息

Second Department of Gynecology and Obstetrics, University of Perugia, Policlinico Monteluce, Italy.

出版信息

Am J Obstet Gynecol. 1989 Feb;160(2):514-7. doi: 10.1016/0002-9378(89)90484-5.

DOI:10.1016/0002-9378(89)90484-5

PMID:2916641

Abstract

CA 125 antigen was measured in amniotic fluid, maternal blood, cord blood, and fetal urine by a commercially available immunoradiometric assay kit. The amniotic fluid was obtained from 99 normal pregnancies at various gestational ages. The mean antigen levels were 29,676, 3350, and 1680 U/ml in amniotic fluid of the first, second, and third trimesters, respectively. In maternal blood, 12.5% of pregnant women in the first trimester of pregnancy showed elevated levels of CA 125 (65 to 100 U/ml). Late in gestation, CA 125 levels in cord blood and fetal urine were always less than 65 U/ml. Immunohistochemical study of CA 125 in fetal membranes, placenta, and decidua showed the presence of antigen only in the amnion. These results suggest that CA 125 is shed into amniotic fluid directly from the amniotic membrane.

摘要

采用市售免疫放射分析试剂盒检测羊水、母血、脐血和胎儿尿液中的CA 125抗原。从99例不同孕周的正常妊娠中获取羊水。妊娠第一、二、三期羊水中CA 125抗原的平均水平分别为29,676、3350和1680 U/ml。在母血中，妊娠早期12.5%的孕妇CA 125水平升高（65至100 U/ml）。妊娠晚期，脐血和胎儿尿液中的CA 125水平始终低于65 U/ml。对胎膜、胎盘和蜕膜进行CA 125免疫组化研究显示，仅羊膜中存在抗原。这些结果表明，CA 125是直接从羊膜释放到羊水中的。