Radlinger Bernhard, Ramoser Gabriele, Kaser Susanne
Department of Internal Medicine 1, Medical University Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria.
Department of Pediatrics II, Medical University Innsbruck, Innsbruck, Austria.
Curr Diab Rep. 2020 Apr 1;20(6):18. doi: 10.1007/s11892-020-01304-0.
Type 1 and type 2 diabetes are often accompanied by mostly mild forms of exocrine pancreatic insufficiency. Despite high prevalence, little is known about the clinical consequences of exocrine pancreatic insufficiency and its optimal (nutritional) treatment. Even less is known if and to what extent exocrine pancreas insufficiency also affects glycemic control in diabetes. This article aims for summarizing current clinical knowledge on screening, diagnosis, and treatment and gives an overview on the pathophysiology of exocrine pancreatic insufficiency in diabetes.
Recent studies reveal novel insights into the close interaction of acinar, ductal, and endocrine cells and the gut-pancreas axis. Exocrine pancreatic insufficiency is a clinically relevant, frequent but poorly understood disorder in both type 1 and type 2 diabetes.
1型和2型糖尿病常伴有大多为轻度形式的外分泌性胰腺功能不全。尽管患病率很高，但对于外分泌性胰腺功能不全的临床后果及其最佳（营养）治疗知之甚少。关于外分泌性胰腺功能不全是否以及在何种程度上也会影响糖尿病患者的血糖控制，了解得更少。本文旨在总结目前关于筛查、诊断和治疗的临床知识，并概述糖尿病中外分泌性胰腺功能不全的病理生理学。
最近的研究揭示了腺泡细胞、导管细胞和内分泌细胞以及肠-胰腺轴之间密切相互作用的新见解。外分泌性胰腺功能不全在1型和2型糖尿病中都是一种临床相关、常见但了解不足的病症。
