Kim Mi Hee, Choi Jung Hyun
Division of Infectious Disease, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Infect Chemother. 2020 Mar;52(1):1-18. doi: 10.3947/ic.2020.52.1.1.
Sepsis is a dysregulated systemic reaction to a common infection, that can cause life-threatening organ dysfunction. Over the last decade, the mortality rate of patients with sepsis has decreased as long as patients are treated according to the recommendations of the Surviving Sepsis Campaign, but is still unacceptably high. Patients at risk of sepsis should therefore be identified prior to the onset of organ dysfunction and this requires a rapid diagnosis and a prompt initiation of treatment. Unfortunately, there is no gold standard for the diagnosis of sepsis and traditional standard culture methods are time-consuming. Recently, in order to overcome these limitations, biomarkers which could help in predicting the diagnosis and prognosis of sepsis, as well as being useful for monitoring the response to treatments, have been identified. In addition, recent advances have led to the development of newly identified classes of biomarkers such as microRNAs, long-non-coding RNAs, and the human microbiome. This review focuses on the latest information on biomarkers that can be used to predict the diagnosis and prognosis of sepsis.
脓毒症是机体对常见感染的一种失调的全身性反应，可导致危及生命的器官功能障碍。在过去十年中，只要按照拯救脓毒症运动的建议对患者进行治疗，脓毒症患者的死亡率就会下降，但仍然高得令人无法接受。因此，应该在器官功能障碍发作之前识别出有脓毒症风险的患者，而这需要快速诊断并及时开始治疗。不幸的是，脓毒症的诊断没有金标准，传统的标准培养方法耗时较长。最近，为了克服这些局限性，已经确定了一些生物标志物，它们有助于预测脓毒症的诊断和预后，还可用于监测治疗反应。此外，最近的进展促使了新发现的几类生物标志物的发展，如微小RNA、长链非编码RNA和人类微生物组。这篇综述重点关注可用于预测脓毒症诊断和预后的生物标志物的最新信息。
