Food Science and Technology Program, Beijing Normal University-Hong Kong Baptist University United International College, 2000, Jintong Road, Tangjiawan, Zhuhai, 519087, Guangdong, China.
Mol Biol Rep. 2020 Apr;47(4):2793-2799. doi: 10.1007/s11033-020-05399-2. Epub 2020 Apr 2.
Blood glucose homeostasis and insulin signaling pathway regulation take a vital role in the management of diabetes mellitus. Our present was designed to explore the mechanism of the blood homeostasis, regulation of oxidative stress and insulin signaling pathway by guava leaf extract (GLE). Diabetes mellitus was induced in male albino Wistar by streptozotocin (STZ) (Single dose-40 mg/kg b.w.). As an extension STZ rats received GLE (GLE; 200 mg/kg b.w). At the end of the study the lipid peroxidation products, antioxidants, insulin signaling genes were analyzed. Treatment with GLE resulted in decreased plasma and skeletal muscle lipid peroxidation markers, increased antioxidants, and improved insulin signaling genes. GLE treatment helps to maintain blood homeostasis alleviates oxidative stress and regulates the insulin signaling genes in skeletal muscle. Overall the results suggest GLE treatment regulates blood glucose, inhibits oxidative stress, and importantly it regulates insulin signaling pathway genes in skeletal muscle. Further studies on the GLE role in other important pathways can add additional strength to the claim that GLE is a strong anti-diabetic candidate.
血糖稳态和胰岛素信号通路调节在糖尿病的管理中起着至关重要的作用。本研究旨在探讨番石榴叶提取物（GLE）对血糖稳态、氧化应激和胰岛素信号通路调节的作用机制。雄性白化 Wistar 大鼠用链脲佐菌素（STZ）（单剂量 40mg/kg b.w.）诱导糖尿病。作为延伸，STZ 大鼠给予 GLE（GLE；200mg/kg b.w.）。研究结束时，分析了脂质过氧化产物、抗氧化剂和胰岛素信号通路基因。GLE 治疗可降低血浆和骨骼肌脂质过氧化标志物，增加抗氧化剂，并改善胰岛素信号通路基因。GLE 治疗有助于维持血糖稳态，减轻氧化应激，并调节骨骼肌中的胰岛素信号通路基因。总的来说，这些结果表明 GLE 治疗可调节血糖、抑制氧化应激，并可调节骨骼肌中的胰岛素信号通路基因。进一步研究 GLE 在其他重要途径中的作用，可以为 GLE 是一种强有力的抗糖尿病候选药物的说法提供更多的支持。
