Department of Applied Nutrition, Faculty of Livestock, Fisheries & Nutrition, Wayamba University of Sri Lanka, Makandura, Gonawila, 60170, Sri Lanka.
Department of Biochemistry, Faculty of Medicine, University of Peradeniya, Sri Lanka.
Oxid Med Cell Longev. 2019 Aug 5;2019:9471697. doi: 10.1155/2019/9471697. eCollection 2019.
Glycaemic control is the main focus of managing diabetes and its complications. Hyperglycaemia induces oxidative stress favouring cellular damage and subsequent diabetic complications. The present study was conducted to compare the plasma total antioxidant capacity (TAC) and individual antioxidant marker antioxidant status of type 2 diabetics (T2D) with good ((+) GC) and poor ((-) GC) glycaemic control with prediabetic (PDM) and normoglycaemic (NG) individuals. T2D ( = 147), PDM ( = 47), and NGC ( = 106) were recruited as subjects. T2D and PDM had lower plasma TAG than NG subjects. T2D and PDM had significantly higher GPx activity and plasma MDA concentrations than NG. PDM showed the highest SOD activity. T2D (-) GC showed significantly elevated GPx activity and higher MDA level and significantly lower SOD activity among all study groups. Lower plasma TAC and higher plasma MDA indicate the presence of oxidative stress in T2D and PDM. Elevated GPx activity in T2D, PDM, and particularly in T2D (-) GC suggests a compensatory response to counteract excess lipid peroxidation in the hyperglycaemic state. Decline in SOD activity advocates the presence of glycation and excess lipid peroxidation in T2D.
血糖控制是管理糖尿病及其并发症的主要重点。高血糖会引起氧化应激，有利于细胞损伤和随后的糖尿病并发症。本研究旨在比较血糖控制良好（+GC）和不佳（-GC）的 2 型糖尿病（T2D）患者与糖尿病前期（PDM）和血糖正常（NG）个体的血浆总抗氧化能力（TAC）和个体抗氧化标志物的抗氧化状态。招募了 147 名 T2D、47 名 PDM 和 106 名 NGC 作为研究对象。T2D 和 PDM 的血浆 TAG 水平低于 NG 组。T2D 和 PDM 的 GPx 活性和血浆 MDA 浓度显著高于 NG。PDM 的 SOD 活性最高。与所有研究组相比，T2D（-）GC 的 GPx 活性显著升高，MDA 水平更高，SOD 活性更低。较低的血浆 TAC 和较高的血浆 MDA 表明 T2D 和 PDM 存在氧化应激。T2D、PDM 中 GPx 活性升高，尤其是 T2D（-）GC 中 GPx 活性升高，表明在高血糖状态下存在脂质过氧化的代偿反应。SOD 活性下降表明 T2D 中存在糖化和脂质过氧化过度。
