Chen C, Zhang X R, Ju Z Y, He W F
State Key Laboratory of Trauma, Burns, and Combined Injury, Institute of Burn Research, the First Affiliated Hospital of Army Medical University (the Third Military Medical University), Chongqing Key Laboratory for Disease Proteomics, Chongqing 400038, China.
Institute of Aging and Regenerative Medicine, Jinan University, Guangzhou 510632, China.
Zhonghua Shao Shang Za Zhi. 2020 Jun 20;36(6):471-475. doi: 10.3760/cma.j.cn501120-20200224-00088.
Coronavirus disease 2019 (COVID-19) has seriously affected the safety of patients and social stability. Some COVID-19 patients in the later stage of disease may develop into acute respiratory distress syndrome or even multiple organ failure. However, one of the most important mechanisms underlying the deterioration of disease is cytokine storm. At present, some therapies such as interleukin-6 antibody blocker, stem cell therapy, and transfusion of convalescent plasma have been applied to counteract the cytokine storm with some progresses being achieved. This article reviews the influences of cytokine storm syndrome on the COVID-19 and the corresponding immunotherapies to resist cytokine storm.
2019冠状病毒病(COVID-19)严重影响了患者安全和社会稳定。部分COVID-19患者在疾病后期可能发展为急性呼吸窘迫综合征甚至多器官功能衰竭。然而,疾病恶化的最重要机制之一是细胞因子风暴。目前,白细胞介素-6抗体阻断剂、干细胞疗法、输注康复期血浆等一些疗法已被应用于对抗细胞因子风暴,并取得了一定进展。本文综述了细胞因子风暴综合征对COVID-19的影响以及抵抗细胞因子风暴的相应免疫疗法。