Federal University of Ceará (UFC), Department of Chemical Engineering, Bloco 709, 60455-760, Fortaleza, Ceará, Brazil.
Embrapa Agroindústria Tropical - CNPAT, Rua Dra Sara Mesquita 2270, Pici, 60511-110, Fortaleza, Ceará, Brazil.
Carbohydr Polym. 2020 Jun 1;237:116174. doi: 10.1016/j.carbpol.2020.116174. Epub 2020 Mar 17.
Hydroxyapatite-associated bacterial cellulose (BC/HA) is a promising composite for biomedical applications. However, this hybrid composite has some limitations due to its low in vivo degradability. The objective of this work was to oxidize BC and BC/HA composites for different time periods to produce 2,3 dialdehyde cellulose (DAC). The BC and oxidized BC (OxBC) membranes were mineralized to obtain the hybrid materials (BC/HA and OxBC/HA) and their physico-chemical, degradability, and bioactivity properties were studied. The results showed that OxBC/HA was more bioactive and degradable than BC/HA, which isa function of the degree of BC oxidation. High glucose levels in the BC degradation were observed as a function of oxidation degree, and other products, such as butyric acid and acetic acid resulted from DAC degradation. Therefore, this chemical modification reaction favors BC degradation, making it a good biodegradable and bioactive material with a potential for bone regeneration applications.
羟基磷灰石相关细菌纤维素（BC/HA）是一种有前途的生物医学应用复合材料。然而，由于其体内降解性低，这种杂化复合材料存在一些局限性。本工作的目的是氧化 BC 和 BC/HA 复合材料不同时间以制备 2,3 二醛纤维素（DAC）。将 BC 和氧化 BC（OxBC）膜矿化以获得杂化材料（BC/HA 和 OxBC/HA），并研究了它们的物理化学、降解性和生物活性性质。结果表明，OxBC/HA 比 BC/HA 更具生物活性和降解性，这是 BC 氧化程度的函数。随着氧化程度的增加，观察到 BC 降解过程中葡萄糖水平升高，并且 DAC 降解还产生了丁酸和乙酸等其他产物。因此，这种化学修饰反应有利于 BC 的降解，使其成为一种具有潜在骨再生应用的良好可生物降解和生物活性材料。
