School of Dentistry/Unesp, São Paulo State University - Unesp, Rua Humaitá, 1680, 14801-903, Araraquara, SP, Brazil.
Institute of Chemistry, São Paulo State University - Unesp, CP 355, Araraquara, SP, 14801-970, Brazil.
Carbohydr Polym. 2016 Nov 20;153:406-420. doi: 10.1016/j.carbpol.2016.07.059. Epub 2016 Jul 19.
Bacterial cellulose (BC) produced by some bacteria, among them Gluconacetobacter xylinum, which secrets an abundant 3D networks fibrils, represents an interesting emerging biocompatible nanomaterial. Since its discovery BC has shown tremendous potential in a wide range of biomedical applications, such as artificial skin, artificial blood vessels and microvessels, wound dressing, among others. BC can be easily manipulated to improve its properties and/or functionalities resulting in several BC based nanocomposites. As example BC/collagen, BC/gelatin, BC/Fibroin, BC/Chitosan, etc. Thus, the aim of this review is to discuss about the applicability in biomedicine by demonstrating a variety of forms of this biopolymer highlighting in detail some qualities of bacterial cellulose. Therefore, various biomedical applications ranging from implants and scaffolds, carriers for drug delivery, wound-dressing materials, etc. that were reported until date will be presented.
细菌纤维素 (BC) 由某些细菌产生,其中包括木醋酸杆菌,它分泌丰富的 3D 纤维网络,是一种很有前途的新兴生物相容性纳米材料。自发现以来,BC 在广泛的生物医学应用中显示出了巨大的潜力,例如人造皮肤、人造血管和微血管、伤口敷料等。BC 可以很容易地进行处理以改善其性能和/或功能,从而产生了几种基于 BC 的纳米复合材料。例如 BC/胶原蛋白、BC/明胶、BC/丝素、BC/壳聚糖等。因此,本综述的目的是通过展示这种生物聚合物的各种形式来讨论其在生物医学中的适用性,详细介绍细菌纤维素的一些特性。因此,将介绍迄今为止报道的各种生物医学应用,包括植入物和支架、药物输送载体、伤口敷料材料等。