偏头痛患者血清维生素 D 水平：一项荟萃分析。

Vitamin D serum levels in patients with migraine: A meta-analysis.

机构信息

Department of Neurology, University Hospital of Larissa, School of Medicine, University of Thessaly, Biopolis, Mezourlo Hill, Larissa 41100, Greece.

出版信息

Rev Neurol (Paris). 2020 Sep;176(7-8):560-570. doi: 10.1016/j.neurol.2019.12.008. Epub 2020 Mar 30.

DOI:10.1016/j.neurol.2019.12.008

PMID:32241571

Abstract

BACKGROUND/PURPOSE: Dietary habits and nutrients have been associated with migraine. The present study comprises a meta-analysis of observational studies evaluating serum levels of 25-hydroxyvitamin D (25(OH)D) in patients with migraine and healthy controls.

METHODS

MEDLINE and Cochrane databases were comprehensively searched. References from retrieved observational studies, reviews and meta-analyses were manually screened. Quality assessment was performed based on the Newcastle-Ottawa Scale. 25(OH)D concentrations were assessed by estimates of mean differences (MD) and their precision [95% confidence intervals (95% CIs)]. Random effects (RE) or fixed effects (FE) model was used based on heterogeneity among trials (homogeneity determined when PQ>0.1 and I2<50%). Publication bias was assessed by funnel plots.

RESULTS

Eight studies were included in the primary analysis, while nine studies were involved overall (in primary and secondary analyses). Serum levels of 25(OH)D were determined significantly lower in migraine patients (n=952) in comparison with healthy controls (n=8013) [eight studies, PQ<0.1, I2=94%, RE model MD=-4.11, 95% CI=(-6.48, -1.74)]. Secondary analysis revealed no difference between patients with migraine (n=269) compared to patients with other primary headache disorders (n=223) [three studies, PQ=0.51, I2=0%, FE model MD=-0.15, 95% CI=(-1.57, 1.05)], as well as between patients with tension type headache (n=295) in comparison with healthy controls (n=267) [three studies, PQ<0.1, I2=96%, RE model MD=-7.11, 95% CI=(-15.50, 1.27)].

CONCLUSIONS

25(OH)D concentration is lower in patients with migraine than healthy individuals. In view of this finding, investigation of the effect of vitamin D supplementation in patients suffering from migraine is warranted.

摘要

背景/目的：饮食习惯和营养素与偏头痛有关。本研究对评估偏头痛患者和健康对照者血清 25-羟维生素 D（25（OH）D）水平的观察性研究进行了荟萃分析。

方法

全面检索 MEDLINE 和 Cochrane 数据库。从检索到的观察性研究、综述和荟萃分析的参考文献中手动筛选。根据纽卡斯尔-渥太华量表进行质量评估。25（OH）D 浓度通过均值差（MD）及其精度[95%置信区间（95%CI）]进行评估。根据试验之间的异质性（当 PQ>0.1 和 I2<50%时确定同质性），使用随机效应（RE）或固定效应（FE）模型。通过漏斗图评估发表偏倚。

结果

共有八项研究纳入主要分析，共有九项研究纳入（主要和次要分析）。与健康对照组（n=8013）相比，偏头痛患者（n=952）的血清 25（OH）D 水平明显较低[八项研究，PQ<0.1，I2=94%，RE 模型 MD=-4.11，95%CI=（-6.48，-1.74）]。二次分析显示，偏头痛患者（n=269）与其他原发性头痛障碍患者（n=223）[三项研究，PQ=0.51，I2=0%，FE 模型 MD=-0.15，95%CI=（-1.57，1.05）]之间以及紧张性头痛患者（n=295）与健康对照组（n=267）[三项研究，PQ<0.1，I2=96%，RE 模型 MD=-7.11，95%CI=（-15.50，1.27）]之间无差异。