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Excellent proliferation and persistence of allogeneic donor-derived 41-BB based CAR-T cells despite immunosuppression with cyclosporine A.

作者信息

Ayuk Francis, Fehse Boris, Janson Dietlinde, Berger Carolina, Riecken Kristoffer, Kröger Nicolaus

机构信息

Department of Stem Cell Transplantation with Research Department Cell and Gene Therapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

Department of Stem Cell Transplantation with Research Department Cell and Gene Therapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

出版信息

Haematologica. 2020 Jun;105(6):322-324. doi: 10.3324/haematol.2019.245969. Epub 2020 Apr 2.

DOI:10.3324/haematol.2019.245969
PMID:32241845
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7271598/
Abstract
摘要

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本文引用的文献

1
Tisagenlecleucel in Adult Relapsed or Refractory Diffuse Large B-Cell Lymphoma.Tisagenlecleucel 治疗成人复发或难治性弥漫性大 B 细胞淋巴瘤。
N Engl J Med. 2019 Jan 3;380(1):45-56. doi: 10.1056/NEJMoa1804980. Epub 2018 Dec 1.
2
Tisagenlecleucel in Children and Young Adults with B-Cell Lymphoblastic Leukemia.替沙格赛定用于治疗儿童和年轻成人B细胞淋巴细胞白血病
N Engl J Med. 2018 Feb 1;378(5):439-448. doi: 10.1056/NEJMoa1709866.
3
Posttransplant chimeric antigen receptor therapy.移植后嵌合抗原受体治疗。
Blood. 2018 Mar 8;131(10):1045-1052. doi: 10.1182/blood-2017-08-752121. Epub 2018 Jan 22.
4
Axicabtagene Ciloleucel CAR T-Cell Therapy in Refractory Large B-Cell Lymphoma.阿基仑赛注射液嵌合抗原受体T细胞疗法治疗难治性大B细胞淋巴瘤
N Engl J Med. 2017 Dec 28;377(26):2531-2544. doi: 10.1056/NEJMoa1707447. Epub 2017 Dec 10.
5
Intent-to-treat leukemia remission by CD19 CAR T cells of defined formulation and dose in children and young adults.采用特定配方和剂量的CD19嵌合抗原受体T细胞对儿童和青年白血病患者进行意向性治疗缓解。
Blood. 2017 Jun 22;129(25):3322-3331. doi: 10.1182/blood-2017-02-769208. Epub 2017 Apr 13.
6
Donor CD19 CAR T cells exert potent graft-versus-lymphoma activity with diminished graft-versus-host activity.供体CD19嵌合抗原受体T细胞具有强大的抗淋巴瘤活性，同时移植物抗宿主活性降低。
Nat Med. 2017 Feb;23(2):242-249. doi: 10.1038/nm.4258. Epub 2017 Jan 9.
7
Phase I trials using Sleeping Beauty to generate CD19-specific CAR T cells.使用睡美人转座子系统生成CD19特异性嵌合抗原受体T细胞的I期试验。
J Clin Invest. 2016 Sep 1;126(9):3363-76. doi: 10.1172/JCI86721. Epub 2016 Aug 2.
8
Allogeneic T Cells That Express an Anti-CD19 Chimeric Antigen Receptor Induce Remissions of B-Cell Malignancies That Progress After Allogeneic Hematopoietic Stem-Cell Transplantation Without Causing Graft-Versus-Host Disease.表达抗CD19嵌合抗原受体的同种异体T细胞可诱导异基因造血干细胞移植后进展的B细胞恶性肿瘤缓解，且不引起移植物抗宿主病。
J Clin Oncol. 2016 Apr 1;34(10):1112-21. doi: 10.1200/JCO.2015.64.5929. Epub 2016 Jan 25.
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Tolerance and efficacy of autologous or donor-derived T cells expressing CD19 chimeric antigen receptors in adult B-ALL with extramedullary leukemia.表达CD19嵌合抗原受体的自体或供体来源T细胞在伴有髓外白血病的成人B淋巴细胞白血病中的耐受性和疗效
Oncoimmunology. 2015 May 26;4(11):e1027469. doi: 10.1080/2162402X.2015.1027469. eCollection 2015 Nov.
10
The effects of Cyclosporine A and azathioprine on human T cells activated by different costimulatory signals.环孢素 A 和硫唑嘌呤对不同共刺激信号激活的人 T 细胞的影响。
Immunol Lett. 2011 Oct 30;140(1-2):74-80. doi: 10.1016/j.imlet.2011.06.010. Epub 2011 Jul 2.