Department of Biosystems Science & Engineering (D-BSSE), ETH Zurich, Switzerland.
Department of Health Sciences & Technology (D-HEST), ETH Zurich, Switzerland.
Nat Rev Mol Cell Biol. 2020 May;21(5):247-248. doi: 10.1038/s41580-020-0242-z.
Coronaviruses employ various nuclear signalling mechanisms for their propagation. Here we link replication of coronaviruses, including SARS-CoV-2, the coronavirus disease 2019 (COVID-19)-causing virus, with cytoskeleton-dependent signalling and 3D genome organization. This link could provide novel insights into the high coronavirus pathogenicity in certain cellular states, particularly those associated with ageing.
冠状病毒采用各种核信号机制来进行繁殖。在这里，我们将冠状病毒（包括导致 2019 年冠状病毒病（COVID-19）的 SARS-CoV-2 病毒）的复制与依赖于细胞骨架的信号转导和 3D 基因组组织联系起来。这一联系可以为理解某些细胞状态下冠状病毒的高致病性提供新的见解，特别是与衰老相关的状态。
