Uhler Caroline, Shivashankar G V
Department of Biosystems Science & Engineering (D-BSSE), ETH Zurich, Switzerland.
Department of Health Sciences & Technology (D-HEST), ETH Zurich, Switzerland.
Curr Opin Solid State Mater Sci. 2021 Feb;25(1):100874. doi: 10.1016/j.cossms.2020.100874. Epub 2020 Nov 6.
In this Current Opinion, we highlight the importance of the material properties of tissues and how alterations therein, which influence epithelial-to-mesenchymal transitions, represent an important layer of regulation in a number of diseases and potentially also play a critical role in host-pathogen interactions. In light of the current SARS-CoV-2 pandemic, we here highlight the possible role of lung tissue stiffening with ageing and how this might facilitate increased SARS-CoV-2 replication through matrix-stiffness dependent epithelial-to-mesenchymal transitions of the lung epithelium. This emphasizes the need for integrating material properties of tissues in drug discovery programs.
在本《当前观点》中，我们强调了组织材料特性的重要性，以及其中的改变如何影响上皮-间质转化，这在许多疾病中代表了一个重要的调控层面，并且在宿主-病原体相互作用中可能也起着关键作用。鉴于当前的新冠疫情，我们在此强调肺组织随年龄增长而变硬的可能作用，以及这如何通过依赖基质硬度的肺上皮上皮-间质转化促进新冠病毒复制增加。这凸显了在药物研发项目中整合组织材料特性的必要性。
