State Key Laboratory of Food Nutrition and Safety, Key Laboratory of Industrial Fermentation Microbiology, College of Biotechnology, Tianjin University of Science and Technology, Tianjin, China.
Food Funct. 2020 Apr 30;11(4):2898-2909. doi: 10.1039/c9fo03015h.
Vinegar extract is rich in phenolic compounds, which can prevent free radical-induced diseases. The aim of the present study was to explore the effects of vinegar extract on gut microbiota in alcohol-treated mice and their correlation with alcohol-induced liver damage. These results showed that vinegar extract regulated the gut microbiota composition and improved intestinal homeostasis through increasing the expression levels of ZO-1, occludin, claudin-1, Reg3b, and Reg3g in alcohol-treated mice. In addition, vinegar extract inhibited the alcohol-induced production of ROS and inflammatory factors. Moreover, Bacteroidetes, Verrucomicrobia, Akkermansia, and Lactobacillus showed a significant positive correlation with Reg3b, Reg3g, ZO-1, occludin, and claudin-1 and a negative correlation with hepatic inflammation and oxidative stress parameters. However, Firmicutes, Proteobacteria, Butyricimonas, Parabacteroides, and Bilophila exhibited the opposite effect. These findings suggest that vinegar extract modulates gut microbiota and improves intestinal homeostasis, and can be used as a novel gut microbiota manipulator against alcohol-induced liver damage.
醋提取物富含酚类化合物，可预防自由基诱导的疾病。本研究旨在探讨醋提取物对酒精处理小鼠肠道微生物群的影响及其与酒精性肝损伤的相关性。这些结果表明，醋提取物通过增加酒精处理小鼠中 ZO-1、occludin、claudin-1、Reg3b 和 Reg3g 的表达水平来调节肠道微生物群组成并改善肠道内稳态。此外，醋提取物抑制了酒精诱导的 ROS 和炎症因子的产生。此外，拟杆菌门、疣微菌门、阿克曼氏菌和乳杆菌与 Reg3b、Reg3g、ZO-1、occludin 和 claudin-1 呈显著正相关，与肝炎症和氧化应激参数呈负相关。然而，厚壁菌门、变形菌门、丁酸单胞菌、副拟杆菌和双岐杆菌则表现出相反的效果。这些发现表明，醋提取物可调节肠道微生物群并改善肠道内稳态，可作为一种新型的肠道微生物群调节剂用于防治酒精性肝损伤。
