Department of Psychological Medicine, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK.
Department of Psychology and Human Development, University College London, London, UK.
Eur Eat Disord Rev. 2020 Jul;28(4):433-444. doi: 10.1002/erv.2736. Epub 2020 Apr 3.
A significant proportion of individuals with anorexia nervosa (AN) show high levels of autism spectrum disorder (ASD) traits, a factor associated with poorer treatment outcomes. An important question for both researchers and clinicians relates to how ASD traits should be assessed in individuals with AN. This study aimed to examine scores on the Social Responsiveness Scale adult self-report version (SRS-2) in individuals in the acute (AN) and recovered stages (REC) of illness compared to healthy controls (HCs). We also aimed to examine associations between the SRS-2 and an observational diagnostic measure, the Autism Diagnostic Observation Schedule - second edition (ADOS-2).
The SRS-2 and ADOS-2 were administered to 142 adults with AN, REC, and HCs. Eating disorder (ED) psychopathology and functional impairment were also assessed.
AN and REC scored significantly higher than HCs on the SRS-2. SRS-2 scores significantly predicted ADOS-2 classification and were positively associated with ED psychopathology and functional impairment. SRS-2 scores were not associated with BMI or illness duration.
The SRS-2 may be a useful tool in screening for ASD traits in individuals with AN. Although cross-sectional, the results also suggest ASD symptoms are independent of BMI and persist in individuals recovered from AN.
相当一部分神经性厌食症(AN)患者表现出高水平的自闭症谱系障碍(ASD)特征,这是与治疗效果较差相关的一个因素。对于研究人员和临床医生来说,一个重要的问题是如何在 AN 患者中评估 ASD 特征。本研究旨在比较急性(AN)和恢复期(REC)个体与健康对照组(HCs)的社交反应量表成人自我报告版(SRS-2)评分。我们还旨在研究 SRS-2 与观察性诊断测量工具自闭症诊断观察量表第二版(ADOS-2)之间的关联。
对 142 名 AN、REC 和 HCs 成人进行 SRS-2 和 ADOS-2 评估。还评估了饮食障碍(ED)心理病理学和功能障碍。
AN 和 REC 在 SRS-2 上的得分明显高于 HCs。SRS-2 得分显著预测 ADOS-2 分类,并与 ED 心理病理学和功能障碍呈正相关。SRS-2 得分与 BMI 或疾病持续时间无关。
SRS-2 可能是筛查 AN 患者 ASD 特征的有用工具。尽管是横断面研究,但结果还表明,ASD 症状与 BMI 无关,并在从 AN 中恢复的个体中持续存在。