College of Pharmaceutical Sciences, Hebei University, Baoding 071002, People's Republic of China.
College of Life Sciences, Hebei University, Baoding 071002, People's Republic of China.
J Nat Prod. 2020 Apr 24;83(4):1283-1287. doi: 10.1021/acs.jnatprod.0c00132. Epub 2020 Apr 3.
Dipleosporalones A and B ( and ), two new [2 + 2] azaphilone dimers, were obtained from a marine-derived sp. fungus. The absolute configurations of and were elucidated by calculations of their ECD spectra. Dipleosporalone A () possessed an unprecedented skeleton with an uncommon 6/4/6 ring system. Compounds and showed cytotoxicity about 30-90-fold more potent than that of their monomer pinophilin B.
二孢菌素 A 和 B（和），两个新的[2+2]吖嗪菲酮二聚体，从海洋来源的真菌中获得。和的绝对构型通过计算它们的 ECD 光谱来阐明。二孢菌素 A（）具有前所未有的骨架，具有不常见的 6/4/6 环系统。化合物和比其单体 pinophilin B 显示出约 30-90 倍的细胞毒性。
