Zhuang Baiyan, Li Shuang, Xu Jing, Zhou Di, Yin Gang, Zhao Shihua, Lu Minjie
Department of Magnetic Resonance Imaging, Cardiovascular imaging and intervention Center, Fuwai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Key Laboratory of Cardiovascular Imaging(Cultivation), Chinese Academy of Medical Sciences, Beijing, 100037, China.
J Magn Reson Imaging. 2020 Oct;52(4):1031-1043. doi: 10.1002/jmri.27160. Epub 2020 Apr 3.
Left and right cardiac structures have been shown to provide important prognostic information in patients with various cardiac disorders. They have always been important biomarkers in patients with heart failure and are crucial in the judgment of a variety of heart diseases.
To provide age- and sex-specific reference values of the normal cardiac structure of Chinese adults.
Prospective study.
In all, 200 healthy adult volunteers with 20 men and 20 women in each of five age deciles from 20 to 70 years.
3.0T, steady-state free precession (SSFP), turbo spin-echo (TSE) sequence.
The reference range of cardiac structure values was normalized to age, gender, and body surface area (BSA). The height, weight, blood pressure, and body mass index were measured as well.
Kolmogorov-Smirnov's, independent-sample t-tests, one-way analysis of variance (ANOVA), Pearson's coefficient, and linear regression.
The normalized left atrial (LA) transverse diameter (two-chamber view) at end-systolic, and left ventricular outflow tract diameter (LVOT) were significantly larger in females compared to males (all P < 0.001), while LA volume at end-systole was found higher in males (males: 36.25 ± 10.03 mL vs. females: 32.78 ± 10.27 mL). With increasing age, there was a weak but significant decrease in normalized LA transverse diameter (two-chamber view) at end- systolic (r = -0.25, P < 0.001). The normalized RA volume at end-systole and RVOT diameter showed significant decrease with advancing age (r = -0.22, P = 0.002; r = -0.34, P < 0.001). The indexed left and right ventricular volumes were mostly smaller with advancing age. The LA longitudinal parameters correlated significantly with LA area measured in the two-chamber view at end-systole (r = 0.78, P < 0.001).
Reference values for the morphological parameters of the intracardiac structure by sex and age distribution are provided in a Chinese population.
2 TECHNICAL EFFICACY: Stage 5 J. Magn. Reson. Imaging 2020;52:1031-1043.
已证明心脏左右结构可为各种心脏疾病患者提供重要的预后信息。它们一直是心力衰竭患者的重要生物标志物，在多种心脏病的判断中至关重要。
提供中国成年人正常心脏结构的年龄和性别特异性参考值。
前瞻性研究。
共200名健康成年志愿者，年龄从20岁至70岁，分为五个年龄组，每组20名男性和20名女性。
3.0T，稳态自由进动（SSFP），快速自旋回波（TSE）序列。
将心脏结构值的参考范围根据年龄、性别和体表面积（BSA）进行标准化。同时测量身高、体重、血压和体重指数。
柯尔莫哥洛夫-斯米尔诺夫检验、独立样本t检验、单因素方差分析（ANOVA）、皮尔逊系数和线性回归。
与男性相比，女性收缩末期左心房（LA）横径（双腔视图）和左心室流出道直径（LVOT）明显更大（所有P < 0.001），而男性收缩末期LA容积更高（男性：36.25 ± 10.03 mL vs. 女性：32.78 ± 10.27 mL）。随着年龄增长，收缩末期标准化LA横径（双腔视图）有微弱但显著的下降（r = -0.25，P < 0.001）。收缩末期标准化右心房容积和右心室流出道直径随年龄增长显著下降（r = -0.22，P = 0.002；r = -0.34，P < 0.001）。随着年龄增长，左、右心室指数容积大多变小。LA纵向参数与收缩末期双腔视图中测量的LA面积显著相关（r = 0.78，P < 0.001）。
提供了中国人群按性别和年龄分布的心脏内结构形态学参数的参考值。
2 技术效能：5级 《磁共振成像杂志》2020年；52:1031 - 1043。
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