Melbourne School of Psychological Sciences, The University of Melbourne, Carlton, Victoria, Australia.
School of Psychological Sciences and Turner Institute for Brain and Mental Health, Monash University, Clayton, Victoria, Australia.
Hum Brain Mapp. 2020 Aug 1;41(11):3077-3088. doi: 10.1002/hbm.24999. Epub 2020 Apr 3.
Preferences can change as a consequence of making hard decisions whereby the value of chosen options increases and the value of rejected options decreases. Such choice-induced preference changes have been associated with brain areas detecting choice conflict (anterior cingulate cortex, ACC), updating stimulus value (dorsolateral prefrontal cortex, dlPFC) and supporting memory of stimulus value (hippocampus and ventromedial prefrontal cortex, vmPFC). Here we investigated whether resting-state neuronal activity within these regions is associated with the magnitude of individuals' preference updates. We fitted a dynamic causal model (DCM) to resting-state neuronal activity in the spectral domain (spDCM) and estimated the causal connectivity among core regions involved in preference formation following hard choices. The extent of individuals' choice-induced preference changes were found to be associated with a diminished resting-state excitation between the left dlPFC and the vmPFC, whereas preference consistency was related to a higher resting-state excitation from the ACC to the left hippocampus and vmPFC. Our results point to a model of preference formation during which the dynamic network configurations between left dlPFC, ACC, vmPFC and left hippocampus at rest are linked to preference change or stability.
偏好会随着艰难决策的做出而发生改变，其中选择的选项的价值增加，而被拒绝的选项的价值降低。这种由选择引起的偏好变化与检测选择冲突的大脑区域（扣带回前皮质，ACC）、更新刺激价值（背外侧前额叶皮质，dlPFC）和支持刺激价值记忆（海马体和腹内侧前额叶皮质，vmPFC）有关。在这里，我们研究了这些区域内的静息状态神经元活动是否与个体偏好更新的幅度相关。我们对静息状态的神经元活动进行了频谱域中的动态因果模型拟合（spDCM），并估计了在进行艰难选择后，核心区域之间参与偏好形成的因果连通性。发现个体的选择引起的偏好变化程度与左侧 dlPFC 和 vmPFC 之间的静息状态兴奋减少有关，而偏好一致性与 ACC 到左侧海马体和 vmPFC 的静息状态兴奋增加有关。我们的研究结果指向了一种偏好形成的模型，其中左侧 dlPFC、ACC、vmPFC 和左侧海马体在休息时的动态网络配置与偏好变化或稳定性相关。
