MRC/UVRI and LSHTM Uganda Research Unit, Entebbe 49, Uganda.
Department of Infectious Disease Epidemiology, London School of Hygiene and Tropical Medicine, Keppel Street, London WC 1E, UK.
Int J Environ Res Public Health. 2020 Apr 1;17(7):2401. doi: 10.3390/ijerph17072401.
We determined the prevalence of and risk factors for alcohol misuse and illicit drug use among young Ugandans in fishing communities, a recognised "key population" for human immunodeficiency virus (HIV) infection.
We conducted a cross-sectional survey among young people (15-24 years) in fishing communities in Koome, Uganda, in December 2017-July 2018. Using Audio-Assisted Self-Interviewing, we collected data on socio-demographic characteristics and alcohol use, including the Alcohol Use Disorders Identification Test (AUDIT) and timeline follow-back calendar (TLFB). Blood samples were analysed for HIV, herpes simplex virus 2 (HSV2), and Phosphatidyl ethanol (PEth 16:0/18:1). Urine samples were analysed for illicit drugs.
Among 1281 participants (52.7% male, mean age 20 years), 659 (51.4%) reported ever drinking alcohol, 248 (19.4%) had 12-month-AUDIT ≥ 8, and 261 (20.5%) had whole-blood PEth 16:0/18:1 concentration ≥ 20 ng/mL, indicating significant consumption. In multivariable analyses, PEth 16:0/18:1 ≥ 20ng/mL, AUDIT ≥ 8 and binge drinking (≥6 standard drinks per drinking occasion in the previous month from TLFB) were all strongly associated with older age, low education, smoking, and HSV2. Illicit drug use prevalence was 5.2% and was associated with older age, low education, being single, and smoking.
Levels of alcohol misuse were high among young people in fishing communities and associated with HSV2, a proxy for risky sexual behaviour. Alcohol and illicit drug harm reduction services and HIV prevention programs in Uganda should prioritise young fisherfolk.
我们确定了乌干达渔业社区年轻人群（艾滋病毒感染的“重点人群”）中酒精滥用和非法药物使用的流行率和风险因素。
我们于 2017 年 12 月至 2018 年 7 月在乌干达 Koome 的渔业社区中对年轻人（15-24 岁）进行了横断面调查。使用音频辅助自我访谈，我们收集了社会人口统计学特征和酒精使用情况的数据，包括酒精使用障碍识别测试（AUDIT）和时间线随访日历（TLFB）。对血液样本进行了艾滋病毒、单纯疱疹病毒 2（HSV2）和磷乙醇（PEth 16:0/18:1）分析。尿液样本用于检测非法药物。
在 1281 名参与者中（52.7%为男性，平均年龄 20 岁），659 名（51.4%）报告曾饮酒，248 名（19.4%）12 个月 AUDIT ≥8，261 名（20.5%）全血 PEth 16:0/18:1 浓度≥20ng/mL，表明大量饮酒。多变量分析显示，PEth 16:0/18:1≥20ng/mL、AUDIT≥8 和 binge drinking（TLFB 前一个月内每次饮酒≥6 标准杯）均与年龄较大、受教育程度较低、吸烟和 HSV2 高度相关。非法药物使用的流行率为 5.2%，与年龄较大、受教育程度较低、单身和吸烟有关。
渔业社区年轻人中酒精滥用水平较高，与 HIV 感染的风险性行为的代表 HSV2 有关。乌干达的酒精和非法药物危害减少服务和艾滋病毒预防计划应优先考虑年轻渔民。
