Department of Technology of Cosmetic and Pharmaceutical Products, University of Information Technology and Management in Rzeszow, Kielnarowa 386a, 36-020 Tyczyn, Poland.
Molecules. 2020 Mar 21;25(6):1433. doi: 10.3390/molecules25061433.
For many years, an increasing number of diagnosed atopy and skin problems have been observed. For people affected by the problem of atopy, the selection of skin care products, including cosmetics, is extremely important. Cleansing cosmetics, due to their ability to cause skin irritations and disturb the hydrolipidic barrier, can increase problems with atopic skin. New solutions to reduce the effects of these products on the skin are very important. In this work, the effect of ectoine on the properties of anionic surfactants was analyzed. Based on model systems, analysis of the effect of ectoine on the irritating effect of four anionic surfactants and their ability to solubilize model sebum was performed. Antioxidant activity was also evaluated, and cytotoxic studies were performed on cell cultures. It was shown that the addition of ectoine to the anionic surfactant solutions improves its safety of use. After introducing ectoine to the surfactant solution, a decrease of irritant potential (about 20%) and a decrease in the ability to solubilize of model sebum (about 10-20%) was noted. Addition of ectoine to surfactant solutions also reduced their cytotoxicity by up to 60%. The obtained results indicate that ectoine may be a modern ingredient that improves the safety of cleansing cosmetics.
多年来，越来越多的过敏症和皮肤问题被诊断出来。对于受过敏问题影响的人来说，选择护肤品，包括化妆品，是极其重要的。由于清洁化妆品会引起皮肤刺激和破坏水脂屏障，因此可能会加重特应性皮肤问题。减少这些产品对皮肤影响的新解决方案非常重要。在这项工作中，分析了四氢嘧啶对阴离子表面活性剂性质的影响。基于模型系统，分析了四氢嘧啶对四种阴离子表面活性剂的刺激性和溶解模型皮脂的能力的影响。还评估了抗氧化活性，并对细胞培养物进行了细胞毒性研究。结果表明，向阴离子表面活性剂溶液中添加四氢嘧啶可提高其使用安全性。将四氢嘧啶引入表面活性剂溶液后，刺激性潜力（约 20%）降低，模型皮脂的溶解能力（约 10-20%）降低。向表面活性剂溶液中添加四氢嘧啶还可将其细胞毒性降低多达 60%。研究结果表明，四氢嘧啶可能是一种可提高清洁化妆品安全性的现代成分。
