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评估含有灵芝、舞茸和猴头菇提取物的模型洗面凝胶的美容性能和使用安全性。

Assessment of Cosmetic Properties and Safety of Use of Model Washing Gels with Reishi, Maitake and Lion's Mane Extracts.

机构信息

Department of Technology of Cosmetic and Pharmaceutical Products, Medical College, University of Information Technology and Management in Rzeszow, Sucharskiego 2, 35-225 Rzeszow, Poland.

Department of Analytical Chemistry, Medical University of Lublin, AlejeRaclawickie 1, 20-059 Lublin, Poland.

出版信息

Molecules. 2022 Aug 10;27(16):5090. doi: 10.3390/molecules27165090.

DOI:10.3390/molecules27165090
PMID:36014338
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9412612/
Abstract

Natural cosmetics are becoming more and more popular every day. For this reason, this work investigates the properties of mushroom extracts, which are not as widely used in the cosmetics industry as plant ingredients. Water extracts of (Maitake), (Lion's Mane) and (Reishi) were tested for their antioxidant properties, bioactive substances content, skin cell toxicity, ability to limit TEWL, effect on skin hydration and pH, and skin irritation. Our research showed that Maitake extract contained the highest amount of flavonoids and phenols, and also showed the most effective scavenging of DPPH and ABTS radicals as well as Chelation of Fe and FRAP radicals, which were 39.84% and 82.12% in a concentration of 1000 µg/mL, respectively. All tested extracts did not increase the amount of ROS in fibroblasts and keratinocytes. The addition of mushroom extracts to washing gels reduced the irritating effect on skin, and reduced the intracellular production of free radicals, compared with the cosmetic base. Moreover, it was shown that the analyzedcosmetics had a positive effect on the pH and hydration of the skin, and reduced TEWL.

摘要

天然化妆品越来越受欢迎。因此，这项工作研究了蘑菇提取物的特性，这些提取物在化妆品行业中的使用不如植物成分广泛。我们测试了（舞茸）、（狮子鬃毛菌）和（灵芝）的水提取物的抗氧化性能、生物活性物质含量、皮肤细胞毒性、限制 TEWL 的能力、对皮肤水合作用和 pH 值的影响以及皮肤刺激性。我们的研究表明，舞茸提取物含有最高量的类黄酮和酚类物质，并且在 1000µg/mL 浓度下对 DPPH 和 ABTS 自由基的清除以及 Fe 和 FRAP 自由基的螯合作用也最为有效，分别为 39.84%和 82.12%。所有测试的提取物均未增加成纤维细胞和角质形成细胞中 ROS 的数量。与化妆品基质相比，将蘑菇提取物添加到洁面凝胶中可减少对皮肤的刺激性，并减少细胞内自由基的产生。此外，研究表明，所分析的化妆品对皮肤的 pH 值和水合作用有积极影响，并减少了 TEWL。

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