孕酮用于治疗中枢神经系统疾病：单一分子的多条信号通路 - Suppr

Progesterone for the treatment of central nervous system disorders: the many signaling roads for a single molecule.

作者信息

Gonzalez Susana Laura

机构信息

Universidad de Buenos Aires, Facultad de Medicina, Departamento de Bioquímica Humana, Buenos Aires; Laboratorio de Nocicepción y Dolor Neuropático, Instituto de Biología y Medicina Experimental, CONICET, Buenos Aires, Argentina.

出版信息

Neural Regen Res. 2020 Oct;15(10):1846-1847. doi: 10.4103/1673-5374.280314.

DOI:10.4103/1673-5374.280314

PMID:32246629

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7513974/

Abstract

摘要

相似文献

Progesterone for the treatment of central nervous system disorders: the many signaling roads for a single molecule.孕酮用于治疗中枢神经系统疾病：单一分子的多条信号通路

Neural Regen Res. 2020 Oct;15(10):1846-1847. doi: 10.4103/1673-5374.280314.

Progesterone effects on the oligodendrocyte linage: all roads lead to the progesterone receptor.孕酮对少突胶质细胞谱系的影响：殊途同归至孕酮受体。

Neural Regen Res. 2019 Dec;14(12):2029-2034. doi: 10.4103/1673-5374.262570.

Levels and actions of progesterone and its metabolites in the nervous system during physiological and pathological conditions.在生理和病理条件下，神经系统中孕酮及其代谢物的水平和作用。

Prog Neurobiol. 2014 Feb;113:56-69. doi: 10.1016/j.pneurobio.2013.07.006. Epub 2013 Aug 16.

Progesterone and allopregnanolone in the central nervous system: response to injury and implication for neuroprotection.中枢神经系统中的孕酮和别孕烯醇酮：对损伤的反应及神经保护作用

J Steroid Biochem Mol Biol. 2015 Feb;146:48-61. doi: 10.1016/j.jsbmb.2014.09.001. Epub 2014 Sep 6.

Progesterone as a neurosteroid: actions within the nervous system.孕酮作为一种神经甾体：在神经系统内的作用。

Cell Mol Neurobiol. 1996 Apr;16(2):143-54. doi: 10.1007/BF02088173.

Antecedent short-term central nervous system administration of estrogen and progesterone alters counterregulatory responses to hypoglycemia in conscious male rats.先前对雄性清醒大鼠进行短期中枢神经系统给予雌激素和孕酮会改变其对低血糖的对抗调节反应。

Am J Physiol Endocrinol Metab. 2007 Dec;293(6):E1511-6. doi: 10.1152/ajpendo.00340.2007. Epub 2007 Oct 16.

Progesterone Effects in the Nervous System.孕激素对神经系统的影响。

Anat Rec (Hoboken). 2019 Aug;302(8):1276-1286. doi: 10.1002/ar.24121. Epub 2019 Apr 23.

[Progesterone, eye and nervous system].[孕酮、眼睛与神经系统]

Dtsch Gesundheitsw. 1951 Oct 4;6(40):1127-31; cont-d.

[Progesterone, eye and nervous system].[孕酮、眼睛与神经系统]

Dtsch Gesundheitsw. 1951 Oct 11;6(41):1157-60.

Psychiatric complications of progesterone and oral contraceptives.孕酮及口服避孕药的精神科并发症

J Clin Psychopharmacol. 1981 Nov;1(6):350-67. doi: 10.1097/00004714-198111000-00003.

引用本文的文献

Understanding the female athlete: molecular mechanisms underpinning menstrual phase differences in exercise metabolism.了解女性运动员：运动代谢中月经周期差异的分子机制。

Eur J Appl Physiol. 2023 Mar;123(3):423-450. doi: 10.1007/s00421-022-05090-3. Epub 2022 Nov 19.

From Menopause to Neurodegeneration-Molecular Basis and Potential Therapy.从更年期到神经退行性变-分子基础与潜在治疗策略。

Int J Mol Sci. 2021 Aug 11;22(16):8654. doi: 10.3390/ijms22168654.

Progesterone in the Brain: Hormone, Neurosteroid and Neuroprotectant.脑内的孕激素：激素、神经甾体和神经保护剂。

Int J Mol Sci. 2020 Jul 24;21(15):5271. doi: 10.3390/ijms21155271.

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Effects of progesterone on glucose uptake in neurons of Alzheimer's disease animals and cell models.孕激素对阿尔茨海默病动物和细胞模型神经元葡萄糖摄取的影响。

Life Sci. 2019 Dec 1;238:116979. doi: 10.1016/j.lfs.2019.116979. Epub 2019 Oct 21.

Progesterone receptor-mediated actions and the treatment of central nervous system disorders: An up-date of the known and the challenge of the unknown.孕激素受体介导的作用及中枢神经系统疾病的治疗：已知与未知的挑战更新。

Steroids. 2020 Jan;153:108525. doi: 10.1016/j.steroids.2019.108525. Epub 2019 Oct 18.

Molecular Interplay Between the Sigma-1 Receptor, Steroids, and Ion Channels.σ-1受体、类固醇与离子通道之间的分子相互作用

Front Pharmacol. 2019 Apr 24;10:419. doi: 10.3389/fphar.2019.00419. eCollection 2019.

Allopregnanolone and Progesterone in Experimental Neuropathic Pain: Former and New Insights with a Translational Perspective.在实验性神经病理性疼痛中，别孕烯醇酮和孕酮：具有转化视角的新见解。

Cell Mol Neurobiol. 2019 May;39(4):523-537. doi: 10.1007/s10571-018-0618-1. Epub 2018 Sep 5.

Cerebroprotection by progesterone following ischemic stroke: Multiple effects and role of the neural progesterone receptors.缺血性脑卒中后孕酮的脑保护作用：神经孕酮受体的多种作用和作用机制。

J Steroid Biochem Mol Biol. 2019 Jan;185:90-102. doi: 10.1016/j.jsbmb.2018.07.014. Epub 2018 Jul 19.

Repurposing and repositioning neurosteroids in the treatment of traumatic brain injury: A report from the trenches.神经甾体的再利用和再定位在创伤性脑损伤治疗中的应用：来自前线的报告。

Neuropharmacology. 2019 Mar 15;147:66-73. doi: 10.1016/j.neuropharm.2018.04.006. Epub 2018 Apr 6.

The Progestin Receptor Interactome in the Female Mouse Hypothalamus: Interactions with Synaptic Proteins Are Isoform Specific and Ligand Dependent.孕激素受体互作组在雌性小鼠下丘脑中的研究：与突触蛋白的相互作用具有同种型特异性和配体依赖性。

eNeuro. 2017 Sep 20;4(5). doi: 10.1523/ENEURO.0272-17.2017. eCollection 2017 Sep-Oct.

Progesterone treatment shows greater protection in brain vs. retina in a rat model of middle cerebral artery occlusion: Progesterone receptor levels may play an important role.在大脑中动脉闭塞大鼠模型中，孕酮治疗对大脑的保护作用比对视网膜的保护作用更强：孕酮受体水平可能起重要作用。

Restor Neurol Neurosci. 2016 Nov 22;34(6):947-963. doi: 10.3233/RNN-160672.

A functional progesterone receptor is required for immunomodulation, reduction of reactive gliosis and survival of oligodendrocyte precursors in the injured spinal cord.功能性孕酮受体对于免疫调节、减轻反应性胶质增生以及少突胶质前体细胞在脊髓损伤后的存活是必需的。

J Steroid Biochem Mol Biol. 2015 Nov;154:274-84. doi: 10.1016/j.jsbmb.2015.09.011. Epub 2015 Sep 11.

Enhancement of cell surface expression and receptor functions of membrane progestin receptor α (mPRα) by progesterone receptor membrane component 1 (PGRMC1): evidence for a role of PGRMC1 as an adaptor protein for steroid receptors.孕激素受体膜成分 1（PGRMC1）增强细胞膜孕激素受体 α（mPRα）的表面表达和受体功能：PGRMC1 作为甾体激素受体衔接蛋白的作用证据。

Endocrinology. 2014 Mar;155(3):1107-19. doi: 10.1210/en.2013-1991. Epub 2014 Jan 1.

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Progesterone for the treatment of central nervous system disorders: the many signaling roads for a single molecule.

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