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Progesterone for the treatment of central nervous system disorders: the many signaling roads for a single molecule.

作者信息

Gonzalez Susana Laura

机构信息

Universidad de Buenos Aires, Facultad de Medicina, Departamento de Bioquímica Humana, Buenos Aires; Laboratorio de Nocicepción y Dolor Neuropático, Instituto de Biología y Medicina Experimental, CONICET, Buenos Aires, Argentina.

出版信息

Neural Regen Res. 2020 Oct;15(10):1846-1847. doi: 10.4103/1673-5374.280314.

DOI:10.4103/1673-5374.280314
PMID:32246629
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7513974/
Abstract
摘要

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Effects of progesterone on glucose uptake in neurons of Alzheimer's disease animals and cell models.孕激素对阿尔茨海默病动物和细胞模型神经元葡萄糖摄取的影响。
Life Sci. 2019 Dec 1;238:116979. doi: 10.1016/j.lfs.2019.116979. Epub 2019 Oct 21.
2
Progesterone receptor-mediated actions and the treatment of central nervous system disorders: An up-date of the known and the challenge of the unknown.孕激素受体介导的作用及中枢神经系统疾病的治疗：已知与未知的挑战更新。
Steroids. 2020 Jan;153:108525. doi: 10.1016/j.steroids.2019.108525. Epub 2019 Oct 18.
3
Molecular Interplay Between the Sigma-1 Receptor, Steroids, and Ion Channels.
Int J Mol Sci. 2020 Jul 24;21(15):5271. doi: 10.3390/ijms21155271.
σ-1受体、类固醇与离子通道之间的分子相互作用
Front Pharmacol. 2019 Apr 24;10:419. doi: 10.3389/fphar.2019.00419. eCollection 2019.
4
Allopregnanolone and Progesterone in Experimental Neuropathic Pain: Former and New Insights with a Translational Perspective.在实验性神经病理性疼痛中，别孕烯醇酮和孕酮：具有转化视角的新见解。
Cell Mol Neurobiol. 2019 May;39(4):523-537. doi: 10.1007/s10571-018-0618-1. Epub 2018 Sep 5.
5
Cerebroprotection by progesterone following ischemic stroke: Multiple effects and role of the neural progesterone receptors.缺血性脑卒中后孕酮的脑保护作用：神经孕酮受体的多种作用和作用机制。
J Steroid Biochem Mol Biol. 2019 Jan;185:90-102. doi: 10.1016/j.jsbmb.2018.07.014. Epub 2018 Jul 19.
6
Repurposing and repositioning neurosteroids in the treatment of traumatic brain injury: A report from the trenches.神经甾体的再利用和再定位在创伤性脑损伤治疗中的应用：来自前线的报告。
Neuropharmacology. 2019 Mar 15;147:66-73. doi: 10.1016/j.neuropharm.2018.04.006. Epub 2018 Apr 6.
7
The Progestin Receptor Interactome in the Female Mouse Hypothalamus: Interactions with Synaptic Proteins Are Isoform Specific and Ligand Dependent.孕激素受体互作组在雌性小鼠下丘脑中的研究：与突触蛋白的相互作用具有同种型特异性和配体依赖性。
eNeuro. 2017 Sep 20;4(5). doi: 10.1523/ENEURO.0272-17.2017. eCollection 2017 Sep-Oct.
8
Progesterone treatment shows greater protection in brain vs. retina in a rat model of middle cerebral artery occlusion: Progesterone receptor levels may play an important role.在大脑中动脉闭塞大鼠模型中，孕酮治疗对大脑的保护作用比对视网膜的保护作用更强：孕酮受体水平可能起重要作用。
Restor Neurol Neurosci. 2016 Nov 22;34(6):947-963. doi: 10.3233/RNN-160672.
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A functional progesterone receptor is required for immunomodulation, reduction of reactive gliosis and survival of oligodendrocyte precursors in the injured spinal cord.功能性孕酮受体对于免疫调节、减轻反应性胶质增生以及少突胶质前体细胞在脊髓损伤后的存活是必需的。
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Endocrinology. 2014 Mar;155(3):1107-19. doi: 10.1210/en.2013-1991. Epub 2014 Jan 1.