National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, PR China.
National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, PR China.
J Control Release. 2020 Jun 10;322:555-565. doi: 10.1016/j.jconrel.2020.03.039. Epub 2020 Apr 1.
Extracellular vesicles (EVs) are membrane vesicles with size of nanometers to several micrometers, which are released by most eukaryotic and prokaryotic cells. Recently, EVs-based nanomedicines have achieved remarkable attentions. Five features need to be satisfied for EVs-based nanomedicine to achieve desirable anticancer activity after systemic administration, including long circulation, enhanced tumor accumulation, deep tumor penetration, efficient cellular internalization and drug release. In this review, we summarize recently reported EVs-based nanomedicines for efficient drug delivery based on our defined five features principle theory. Even though EVs-based nanomedicines are in infancy, it is expectable that they exhibit promising prospects for cancer treatment.
细胞外囊泡 (EVs) 是一种大小为纳米到数微米的膜囊泡，由大多数真核和原核细胞释放。最近，基于 EVs 的纳米药物引起了广泛关注。基于 EVs 的纳米药物要实现理想的抗癌活性，需要满足五个特征，包括长循环、增强肿瘤积累、深肿瘤穿透、高效细胞内化和药物释放。在本综述中，我们根据我们定义的五个特征原则理论，总结了最近报道的基于 EVs 的用于有效药物递送的纳米药物。尽管基于 EVs 的纳米药物仍处于起步阶段，但它们有望为癌症治疗展现出广阔的前景。
