Bai Yu-Ting, Zhang Xue-Qiong, Chen Xiao-Jie, Zhou Gang
The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, Wuhan, 430079, China.
School of Chemistry, Chemical Engineering & Life Sciences, Wuhan University of Technology, Wuhan, 430070, China.
Nanomedicine (Lond). 2022 Oct;17(23):1761-1778. doi: 10.2217/nnm-2022-0142. Epub 2023 Jan 17.
Oral cancer is a common life-threatening malignancy having high mortality and morbidity rates. During the treatment process, individuals unavoidably experience severe side effects. It is essential to develop safer and more effective strategies. Currently, extracellular vesicles (EVs) and biomimetic nanoparticles are nanomedicines with long-term blood circulation and lower off-target toxicity that orchestrate immune responses and accumulate specifically in tumor sites. EVs create a synergetic effect by encapsulating drugs and collaborating with naturally loaded elements in the EVs. Biomimetic nanoparticles retain the characteristic features of the synthetic nanocarriers and inherit the intrinsic cell membrane functionalities. This review outlines the properties, applications, challenges, pros and cons of EVs and biomimetic nanoparticles, providing novel perspectives on oral cancer.
口腔癌是一种常见的危及生命的恶性肿瘤，死亡率和发病率都很高。在治疗过程中，患者不可避免地会经历严重的副作用。开发更安全、更有效的治疗策略至关重要。目前，细胞外囊泡（EVs）和仿生纳米颗粒是具有长期血液循环和较低脱靶毒性的纳米药物，它们能协调免疫反应并特异性地在肿瘤部位积聚。EVs通过包裹药物并与EVs中天然负载的成分协同作用，产生协同效应。仿生纳米颗粒保留了合成纳米载体的特征，并继承了内在的细胞膜功能。本文综述了EVs和仿生纳米颗粒的特性、应用、挑战、优缺点，为口腔癌提供了新的视角。
