工程外泌体：肌腱-骨愈合的有前途策略。
Engineered exosomes: a promising strategy for tendon-bone healing.
机构信息
Department of Orthopedics, The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Luzhou, Sichuan 646600, China.
Department of Orthopedics, The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Luzhou, Sichuan 646600, China; Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610000, China.
出版信息
J Adv Res. 2024 Oct;64:155-169. doi: 10.1016/j.jare.2023.11.011. Epub 2023 Nov 14.
BACKGROUND
Due to the spatiotemporal complexity of the composition, structure, and cell population of the tendon-bone interface (TBI), it is difficult to achieve true healing. Recent research is increasingly focusing on engineered exosomes, which are a promising strategy for TBI regeneration.
AIM OF REVIEW
This review discusses the physiological and pathological characteristics of TBI and the application and limitations of natural exosomes in the field of tendon-bone healing. The definition, loading strategies, and spatiotemporal properties of engineered exosomes were elaborated. We also summarize the application and future research directions of engineered exosomes in the field of tendon-bone healing.
KEY SCIENTIFIC CONCEPTS OF REVIEW
Engineered exosomes can spatially deliver cargo to targeted sites and temporally realize the sustained release of therapeutic molecules in TBI. This review expounds on the multidifferentiation of engineered exosomes for tendon-bone healing, which effectively improves the biological and biomechanical properties of TBI. Engineered exosomes could be a promising strategy for tendon-bone healing.
背景
由于肌腱-骨界面（TBI）的组成、结构和细胞群体的时空复杂性，很难实现真正的愈合。最近的研究越来越关注工程外泌体，这是 TBI 再生的一种有前途的策略。
目的
本综述讨论了 TBI 的生理和病理特征，以及天然外泌体在肌腱-骨愈合领域的应用和局限性。阐述了工程外泌体的定义、加载策略和时空特性。我们还总结了工程外泌体在肌腱-骨愈合领域的应用和未来研究方向。
综述的关键科学概念
工程外泌体可以将货物空间递送到靶向部位，并在 TBI 中实现治疗分子的持续释放。本综述阐述了工程外泌体在肌腱-骨愈合中的多向分化，有效改善了 TBI 的生物学和生物力学特性。工程外泌体可能是肌腱-骨愈合的一种有前途的策略。
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