Division of Pediatric Infectious Diseases, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
School of Arts and Sciences, University of Pennsylvania, Philadelphia, PA 19104, USA.
Curr Opin Microbiol. 2020 Feb;53:61-70. doi: 10.1016/j.mib.2020.02.009. Epub 2020 Apr 2.
With more than one million bacterial genome sequences uploaded to public databases in the last 25 years, genomics has become a powerful tool for studying bacterial biology. Here, we review recent approaches that leverage large numbers of whole genome sequences to decipher the spread and pathogenesis of bacterial infectious diseases.
在过去的 25 年中,已有超过一百万的细菌基因组序列被上传到公共数据库中,基因组学已成为研究细菌生物学的有力工具。在这里,我们回顾了最近利用大量全基因组序列来破译细菌传染病传播和发病机制的方法。