Institute of Neuroscience & Psychology, University of Glasgow, Glasgow, UK.
Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands.
Philos Trans R Soc Lond B Biol Sci. 2020 May 25;375(1799):20190226. doi: 10.1098/rstb.2019.0226. Epub 2020 Apr 6.
Our experiences continue to be processed 'offline' in the ensuing hours of both wakefulness and sleep. During these different brain states, the memory formed during our experience is replayed or reactivated. Here, we discuss the unique challenges in studying offline reactivation, the growth in both the experimental and analytical techniques available across different animals from rodents to humans to capture these offline events, the important challenges this innovation has brought, our still modest understanding of how reactivation drives diverse synaptic changes across circuits, and how these changes differ (if at all), and perhaps complement, those at memory formation. Together, these discussions highlight critical emerging issues vital for identifying how reactivation affects circuits, and, in turn, behaviour, and provides a broader context for the contributions in this special issue. This article is part of the Theo Murphy meeting issue 'Memory reactivation: replaying events past, present and future'.
我们的体验会在随后的清醒和睡眠时间里持续以“离线”的方式进行处理。在这些不同的大脑状态下，我们在体验过程中形成的记忆会被重新播放或重新激活。在这里，我们讨论了研究离线再激活所面临的独特挑战，以及从啮齿动物到人等不同动物的实验和分析技术的不断发展，这些技术可用于捕捉这些离线事件。我们还讨论了这一创新带来的重要挑战，以及我们对再激活如何驱动不同回路中的突触变化的理解仍然有限，以及这些变化（如果有的话）是如何不同的，也许可以补充记忆形成过程中的变化。这些讨论共同强调了确定再激活如何影响回路，进而影响行为的关键新问题，为本期特刊中的贡献提供了更广泛的背景。本文是“Theo Murphy 会议议题‘记忆再激活：重播过去、现在和未来的事件’”的一部分。
